TABLE 1

Association of IGF2BP2 SNPs with type 2 diabetes: confirmed susceptibility SNPs rs4402960 and rs1470579 and SNPs showing nominal association (P < 0.05) in French Caucasians

SNPChr. Position (bp) NCBI36Gene region*AlleleAllele count
POR (95% CI)
Type 2 diabetic case subjects (%)Normoglycemic control subjects (%)
rs9826022186,839,9543′ downstreamA2,532 (93.0)2,949 (95.3)0.00021.53 (1.22–1.91)
(+4267 bp)G190 (7.0)145 (4.7)
rs9864104186,840,2253′ downstreamC2,260 (81.7)2,628 (84.2)0.0121.19 (1.04–1.37)
(+3996 bp)T506 (18.3)494 (15.8)
rs4402960186,994,381Intron 6G1,786 (67.5)2,111 (68.1)0.6321.03 (0.92–1.15)
T858 (32.5)987 (31.9)
rs1470579187,011,773Intron 5A1,753 (67.3)2,120 (67.4)0.8961.01 (0.90–1.13)
C853 (32.7)1,024 (32.6)
  • Data are n (%) unless otherwise indicated.

  • *

    * Relative to the NCBI36 coordinates of the IGF2BP2 genomic locus (chr. 3:186,844,221.0.187,025,521). χ2 P values are shown.