TABLE 1

Plasma metabolite and insulin concentrations in 12- and 22-week-old control (lean) and diabetic (ZDF) rats (n = 7)

12 weeks
22 weeks
LeanZDFLeanZDF
Glucose (mmol/l)4.4 ± 0.7910.2 ± 0.73*6.9 ± 0.3517.7 ± 1.92*
NEFA (mEq/l)0.67 ± 0.031.81 ± 0.55*0.88 ± 0.082.45 ± 0.26*
Total ketones (μmol/l)989 ± 53.2212 ± 25.6*919 ± 24.8406 ± 67.6*
Liver triglycerides (mg/g tissue)3.8 ± 0.2215 ± 5.5*3.3 ± 0.2711 ± 0.10*
Insulin (ng/ml)0.22 ± 0.042.6 ± 0.87*0.28 ± 0.021.0 ± 0.15*
  • Data are means ± SE.

  • *

    * P < 0.05 between control and diabetic group.

  • P < 0.05 between young and old groups.