TABLE 2

Plasma metabolite and insulin concentrations in 12-week-old control (lean) and diabetic (ZDF) rats treated with a low or high dose of the PPAR-α agonist WY14,643 (n = 4–7)

Untreated
Low dose
High dose
LeanZDFLean WY14,643ZDFLean WY14,643ZDF WY14,643
Glucose (mmol/l)4.4 ± 0.7910.2 ± 0.73*6.9 ± 0.109.2 ± 0.30*9.8 ± 0.8810.4 ± 0.24
NEFAs (mEq/l)0.67 ± 0.031.81 ± 0.55*0.31 ± 0.050.64 ± 0.08*0.33 ± 0.040.86 ± 0.20*
Total ketones (μmol/l)989 ± 53.2212 ± 25.6*790 ± 39.5482 ± 76.5*886 ± 90.91200 ± 106
Liver triglycerides (mg/g tissue)3.8 ± 0.2215 ± 5.5*3.7 ± 0.5817 ± 4.3*4.8 ± 0.2213 ± 1.6*
Insulin (ng/ml)0.22 ± 0.042.6 ± 0.87*0.13 ± 0.021.2 ± 0.40*0.33 ± 0.100.65 ± 0.07*
  • Data are means ± SE.

  • *

    * P < 0.05 between control and diabetic group.

  • P < 0.05 between treated and untreated groups.