TABLE 2

Associations of seven genes with type 2 diabetes in Chinese and Korean populations

GeneSNPChrPosition (bp)Risk/ non-risk alleles*Hong Kong
Korea SNUH
Korea KHGS
Combined (95% CI)
Case risk AFControl risk AFOR (95% CI)P valueCase risk AFControl risk AFOR (95% CI)P valueCase risk AFControl risk AFOR (95% CI)P valueOR (95% CI)P valuePempirical value
Total n3,0111,3932,3156,719
Case/control subjects1,481/1,530761/632799/1,5163,041/3,678
IGF2BP2rs44029603186994381T/G0.2550.2451.05 (0.93–1.18)0.4130.3310.2961.18 (1.00–1.39)0.0490.3180.2731.24 (1.09–1.42)0.0011.14 (1.06–1.23)8.1 × 10−40.012
CDKAL1rs7754840620769229C/G0.4200.3581.29 (1.17–1.43)1.0 × 10−60.5190.4641.24 (1.07–1.44)0.0050.5290.4681.27 (1.13–1.44)1.0 × 10−41.28 (1.19–1.37)4.6 × 10−121.0 × 10−4
CDKAL1rs7756992620787688G/A0.5170.4621.24 (1.12–1.37)2.9 × 10−50.5860.5261.26 (1.09–1.47)0.0020.6010.5301.33 (1.17–1.50)8.2 × 10−61.28 (1.19–1.37)3.9 × 10−121.0 × 10−4
SLC30A8§rs132666348118253964C/T0.5720.5321.17 (1.06–1.3)0.0020.6270.5851.18 (1.02–1.38)0.0290.5900.5821.03 (0.91–1.17)0.6361.13 (1.05–1.21)6.5 × 10−40.010
CDKN2A/Brs564398922019547C/T0.1080.1021.07 (0.91–1.27)0.4070.1560.1281.24 (1.01–1.54)0.0440.1270.1350.93 (0.77–1.11)0.4211.06 (0.95–1.18)0.2840.978
CDKN2A/Brs1333040922073404T/C0.6920.6751.08 (0.97–1.21)0.1540.6640.6840.91 (0.77–1.07)0.2500.6900.6801.05 (0.92–1.20)0.4771.03 (0.96–1.11)0.4020.998
CDKN2A/Brs10757278922114477G/A0.5240.4951.12 (1.01–1.24)0.0300.4490.4530.98 (0.85–1.14)0.8340.4770.4491.12 (0.99–1.27)0.0691.09 (1.02–1.17)0.0150.167
CDKN2A/Brs10811661922124094T/C0.6140.5681.21 (1.09–1.34)3.5 × 10−40.6190.5121.55 (1.33–1.81)2.0 × 10−80.6010.5461.25 (1.10–1.41)4.4 × 10−41.29 (1.20–1.38)1.3 × 10−121.0 × 10−4
HHEXrs11118751094452862C/T0.3050.2881.09 (0.97–1.21)0.1440.3470.3051.21 (1.03–1.43)0.0190.3520.3091.23 (1.08–1.41)0.0021.16 (1.07–1.24)1.6 × 10−40.003
HHEXrs50154801094455539C/T0.1850.1721.09 (0.95–1.25)0.2280.2190.1861.22 (1.02–1.47)0.0340.2270.1831.32 (1.13–1.54)3.7 × 10−41.20 (1.09–1.31)9.0 × 10−50.002
HHEXrs79238371094471897G/A0.2050.1761.20 (1.06–1.37)0.0050.2620.2101.33 (1.12–1.59)0.0020.2520.2241.17 (1.01–1.35)0.0331.22 (1.12–1.33)3.3 × 10−63.0 × 10−4
TCF7L2rs790314610114748339T/C0.0300.0231.30 (0.95–1.76)0.0990.0370.0251.53 (0.98–2.39)0.0630.0310.0241.29 (0.90–1.87)0.1691.35 (1.10–1.67)0.0050.058
FTOrs80501361652373776A/C0.1560.1361.18 (1.02–1.37)0.0280.1380.1221.15 (0.92–1.44)0.2280.1240.1181.06 (0.88–1.28)0.5351.13 (1.02–1.25)0.0160.177
  • AF, allele frequency; Chr, chromosome.

  • *

    * All alleles were indexed to the forward strand of NCBI Build 36. Risk alleles were defined according to association results from combined samples.

  • ORs (95% CI) were reported with respect to the risk allele using a log additive model in logistic regression.

  • ‡Fixed effects Cochran-Mantel-Haenszel test was shown for meta-analysis in the combined samples.

  • §

    § Rs13266634 assay was failed in the Korea KHGS samples and was replaced by rs3802177.