TABLE 3

Associations of seven genes with metabolic traits in the combined Chinese and Korean control samples

Traitnβ (95% CI)P valuePempirical valueβ (95% CI)P valuePempirical value
IGF2BP2: rs4402960 (T/G)*
CDKAL1: rs7756992 (G/A)*
BMI (kg/m2)3,667−0.022 (−0.074 to 0.029)0.3940.969−0.014 (−0.060 to 0.031)0.5320.996
Fasting glucose (mmol/l)3,6780.008 (−0.044 to 0.060)0.7631.0000.030 (−0.015 to 0.075)0.1960.775
Glucose at 120 min (mmol/l)1,950−0.015 (−0.086 to 0.056)0.6711.000−0.042 (−0.105 to 0.021)0.1900.776
Fasting insulin (pmol/l)2,6620.049 (−0.011 to 0.109)0.1110.563−0.014 (−0.068 to 0.040)0.6090.998
Insulin at 120 min (pmol/l)1,9470.006 (−0.065 to 0.077)0.8681.000−0.011 (−0.073 to 0.052)0.7391.000
HOMA-IR2,6620.052 (−0.008 to 0.112)0.0900.479−0.011 (−0.064 to 0.043)0.6981.000
HOMA-β2,6620.026 (−0.035 to 0.086)0.4060.976−0.014 (−0.068 to 0.039)0.6000.998
SLC30A8: rs13266634 (C/T)*
CDKN2A/B: rs10811661 (T/C)*
BMI (kg/m2)0.010 (−0.036 to 0.057)0.6621.000−0.016 (−0.062 to 0.029)0.4830.992
Fasting glucose (mmol/l)0.055 (0.008–0.102)0.0230.1390.034 (−0.012 to 0.08)0.1520.673
Glucose at 120 min (mmol/l)0.046 (−0.019 to 0.111)0.1620.7180.017 (−0.046 to 0.08)0.6030.998
Fasting insulin (pmol/l)−0.030 (−0.085 to 0.026)0.2910.909−0.002 (−0.055 to 0.052)0.9471.000
Insulin at 120 min (pmol/l)0.054 (−0.010 to 0.119)0.1000.521−0.023 (−0.086 to 0.040)0.4760.990
HOMA-IR−0.022 (−0.077 to 0.034)0.4430.9830.00002 (−0.05352 to 0.05356)0.9991.000
HOMA-β−0.052 (−0.107 to 0.004)0.0670.389−0.011 (−0.065 to 0.043)0.6951.000
HHEX: rs7923837 (G/A)*
TCF7L2: rs7903146 (T/C)*
BMI (kg/m2)−0.033 (−0.090 to 0.024)0.2590.8780.015 (−0.133 to 0.162)0.8461.000
Fasting glucose (mmol/l)0.025 (−0.032 to 0.082)0.3930.9680.051 (−0.096 to 0.199)0.4940.991
Glucose at 120 min (mmol/l)0.013 (−0.064 to 0.089)0.7481.000−0.090 (−0.29 to 0.110)0.3770.967
Fasting insulin (pmol/l)0.005 (−0.061 to 0.071)0.8811.0000.052 (−0.123 to 0.226)0.5600.996
Insulin at 120 min (pmol/l)−0.053 (−0.130 to 0.023)0.1740.744−0.211 (−0.411 to 0.012)0.0380.230
HOMA-IR0.003 (−0.064 to 0.069)0.9321.0000.056 (−0.119 to 0.230)0.5330.996
HOMA-β0.017 (−0.049 to 0.084)0.6060.9980.032 (−0.143 to 0.206)0.7221.000
FTO: rs8050136 (A/C)*
BMI (kg/m2)0.094 (0.024–0.164)0.0080.057
Fasting glucose (mmol/l)−0.004 (−0.074 to 0.066)0.9101.000
Glucose at 120 min (mmol/l)0.024 (−0.072 to 0.120)0.6210.999
Fasting insulin (pmol/l)−0.011 (−0.093 to 0.071)0.7861.000
Insulin at 120 min (pmol/l)0.034 (−0.063 to 0.131)0.4910.992
HOMA-IR−0.007 (−0.089 to 0.075)0.8711.000
HOMA-β−0.011 (−0.093 to 0.071)0.7981.000
  • *

    * Risk alleles/non-risk alleles are indicated in the parentheses as defined according to Table 2.

  • Analyses were performed by combining Z scores of age- and sex-adjusted metabolic traits in the control subjects of four populations separately and then analyzed for association by linear regression. β values, 95% CI, and asymptotic P values (t statistic) are shown. β value represents the difference of Z score in the trait value associated with each copy of the risk allele.