TABLE 4

Meta-analysis of seven genes for type 2 diabetes association in European and Asian populations

GeneChrSNPRisk/ non-risk allelesEuropeans*
Asians
Europeans versus Asians
All populations
Control risk AFOR (95% CI)AR (%)Control risk AFOR (95% CI)AR (%)P for hetero-geneity of OROR (95% CI)
Maximum n55,8268,44764,273
Case/control subjects21,733/34,0933,905/4,54225,638/38,635
IGF2BP23rs4402960T/G0.301.14 (1.11–1.18)8.20.271.12 (1.05–1.20)6.50.6531.14 (1.11–1.17)
CDKAL16rs7756992G/A0.291.14 (1.11–1.17)7.90.501.26 (1.19–1.34)21.60.0031.16 (1.13–1.19)
SLC30A88rs13266634C/T0.671.16 (1.13–1.20)18.60.561.13 (1.07–1.21)13.50.5011.16 (1.13–1.19)
CDKN2A/B9rs10811661T/C0.841.19 (1.14–1.25)25.80.551.27 (1.20–1.36)24.50.1301.22 (1.18–1.26)
HHEX10rs7923837G/A0.601.23 (1.16–1.30)22.50.201.25 (1.16–1.34)9.20.7221.23 (1.18–1.29)
TCF7L210rs7903146T/C0.271.44 (1.40–1.49)20.20.031.44 (1.21–1.72)2.21.0001.44 (1.40–1.49)
FTO16rs8050136A/C0.391.11 (1.08–1.15)8.30.141.16 (1.07–1.27)4.40.3751.12 (1.08–1.15)
  • AF, allele frequency; AR, attributable risk.

  • *

    * Meta-analysis in Europeans was performed by fixed effects Cochran-Mantel-Haenszel test based on available SNPs in all European populations reported in the five genome-wide association studies. The SNPs included from the French study were rs13266634, rs7923837, and rs7903146 (5). The SNPs included from the Icelandic study were rs7756992, rs13266634, rs7923837, and rs7903146 (6). The SNPs included from the DGI, FUSION, and WTCCC studies were rs4402960, rs7754840, rs13266634, rs10811661, rs7903146/rs7901695, and rs8050136 (3,4,8). DerSimonian and Laird random effects OR (95% CI) for SNPs with heterogeneous between-group effects were 1.14 (1.09–1.20) for rs7756992, 1.17 (1.10–1.23) for rs13266634, 1.44 (1.30–1.59) for rs7903146, and 1.12 (1.00–1.26) for rs8050136.

  • Meta-analysis from this study and Horikoshi et al. (17). DerSimonian and Laird random effects OR (95% CI) for SNPs with heterogeneous between-group effects was 1.29 (1.16–1.43) for rs10811661.

  • Meta-analysis by combining European and Asian data.