TABLE 2

Association analysis of FTO sequence variants and obesity

No.SNP nameMajor/ minor alleleGenotype distribution*
Genotypic PnominalMAF
Odds ratio for obesity (95% CI)Allelic Pnominal (adjusted P)Allelic Ppermuted
CaseControlCaseControl
1rs1421092G/A(172:280:179)(356:775:428)0.0180.4940.4761.08 (0.94–1.26)0.26 (0.70)0.96
2rs11861870T/C(119:308:206)(282:766:534)0.810.4320.4211.04 (0.90–1.20)0.60 (0.83)1.0
3rs9939609T/A(18:167:425)(20:347:1158)0.00280.1660.1261.43 (1.16–1.75)7 × 10−4 (0.034)0.0087
4rs16952730A/G(52:268:310)(136:651:784)0.810.2970.2941.02 (0.87–1.19)0.82 (0.69)1.0
5rs16952777C/G(142:313:159)(342:786:425)0.970.4850.4721.01 (0.88–1.17)0.84 (0.32)1.0
6rs4784338T/G(41:315:165)(338:785:432)0.990.4810.4701.01 (0.87–1.16)0.96 (0.27)1.0
7rs1107355G/A(74:312:228)(273:756:542)0.150.3930.4150.88 (0.76–1.02)0.098 (0.42)0.67
8rs12443572C/G(12:171:426)(50:443:1,047)0.160.1600.1760.85 (0.70–1.03)0.097 (0.55)0.67
9rs13331869T/A(11:166:44)(47:436:1,046)0.0800.1520.1740.84 (0.69–1.02)0.077 (0.33)0.58
10rs12600060G/T(119:323:168)(307:766:462)0.610.4600.4501.08 (0.93–1.25)0.31 (0.84)0.98
11rs16952987G/A(80:299:249)(208:707:647)0.580.3660.3601.04 (0.89–1.21)0.64 (0.73)1.0
12rs918031T/C(86:309:233)(246:719:603)0.380.3830.3860.97 (0.84–1.13)0.68 (0.72)1.0
13rs1008400C/T(87:310:231)(249:718:605)0.340.3850.3870.97 (0.83–1.12)0.65 (0.73)1.0
14rs1588413C/T(54:275:297)(118:611:855)0.0290.3060.2681.23 (0.98–1.31)0.011 (0.46)0.12
15rs11076022G/A(142:330:159)(324:811:448)0.280.4860.4621.13 (0.98–1.31)0.10 (0.63)0.68
16rs11076023T/A(117:311:190)(272:744:514)0.310.4410.4221.11 (0.96–1.29)0.16 (0.60)0.85
17rs12597712C/G(119:315:186)(280:771:500)0.400.4460.4291.11 (0.96–1.28)0.16 (0.65)0.86
18rs2072518G/A(137:319:170)(334:801:442)0.650.4740.4661.07 (0.92–1.24)0.36 (0.73)0.99
19rs2075205A/T(153:303:133)(364:776:374)0.360.4830.5030.91 (0.89–1.06)0.22 (0.49)0.93
  • *

    * Genotype distributions are shown as the counts of three genotypes(aa, Aa, and AA). a, minor allele; A, major allele.

  • Adjusted for age, sex, and BMI.

  • Permutation for 10,000 times. MAF, minor allele frequency. Bold indicates P < 0.05.