TABLE 3

Association analysis of FTO sequence variants and type 2 diabetes

No.SNP nameMajor/ minor alleleGenotype distribution*
Genotypic PnominalMAF
Odds ratio for type 2 diabetes (95% CI)Allelic Pnominal (adjusted P)Allelic Ppermuted
CaseControlCaseControl
1rs1421092G/A(178:356:219)(164:376:208)0.500.4730.4691.01 (0.88–1.18)0.83 (0.92)1.0
2rs11861870T/C(136:358:259)(131:377:256)0.770.4190.4201.00 (0.86–1.15)0.95 (0.80)1.0
3rs9939609T/A(11:172:55)(10:166:550)0.940.1320.1271.05 (0.84–1.31)0.67 (0.86)1.0
4rs16952730A/G(61:316:380)(71:314:371)0.650.2890.3020.94 (0.80–1.10)0.44 (0.64)1.0
5rs16952777C/G(154:366:219)(180:384:188)0.0950.4560.4930.86 (0.75–0.99)0.038 (0.056)0.43
6rs4784338T/G(153:370:220)(175:378:194)0.200.4550.4880.88 (0.76–1.01)0.071 (0.14)0.58
7rs1107355G/A(115:369:270)(146:369:246)0.0920.3970.4350.86 (0.74–0.98)0.033 (0.044)0.36
8rs12443572C/G(19:216:50)(23:214:50)0.820.1720.1760.97 (0.77–1.18)0.75 (0.61)1.0
9rs13331869T/A(16:211:499)(23:214:501)0.550.1670.1770.94 (0.77–1.14)0.49 (0.49)1.0
10rs12600060G/T(157:354:223)(139:379:218)0.370.4550.4461.04 (0.89–1.20)0.63 (0.71)1.0
11rs16952987G/A(96:350:308)(101:339:311)0.860.5590.5610.99 (0.86–1.16)0.93 (0.99)1.0
12rs918031T/C(114:344:289)(114:358:285)0.880.4830.4860.99 (0.85–1.18)0.86 (0.90)1.0
13rs1008400C/T(115:344:29)(115:357:284)0.860.3830.3870.98 (0.85–1.14)0.82 (0.86)1.0
14rs1588413C/T(56:295:40)(52:290:423)0.780.2690.2591.05 (0.89–1.24)0.52 (0.55)1.0
15rs11076022G/A(156:386:213)(148:397:223)0.790.4620.4531.04 (0.90–1.20)0.61 (0.60)0.87
16rs11076023T/A(140:351:243)(114:362:25)0.210.4300.4051.11 (0.96–1.29)0.15 (0.17)0.93
17rs12597712C/G(141:366:235)(120:375:249)0.330.4370.4131.10 (0.95–1.28)0.19 (0.21)0.91
18rs2072518G/A(167:378:205)(150:388:228)0.350.4750.4501.10 (0.95–1.28)0.18 (0.16)0.99
19rs2075205A/T(183:367:178)(162:375:185)0.480.5030.4851.07 (0.93–1.25)0.31(0.36)1.0
  • *

    * Genotype distributions are shown as the counts of three genotypes(aa, Aa, and AA). a, minor allele; A, major allele.

  • Adjusted for age, sex, and BMI.

  • Permutation for 10,000 times. MAF, minor allele frequency. Bold indicates P < 0.05.