TABLE 2

Plasmatic renin activity and kidney renin immunoreactivity index

Age (months)
ANOVA
1361218AgeGroupInteraction
Plasma renin activity (μg · ml−1 · h−1)CMO215 ± 16.6175 ± 34163 ± 20.7162 ± 12.6104 ± 5.2
n77795
DMO216 ± 31.3107 ± 13.4104 ± 11.8*140 ± 8.391.1 ± 23.3P < 0.0001P = 0.021P = 0.4022
n85884
Renal renin expression (arbitrary unit)CMO51.9 ± 2.454.4 ± 6.163.7 ± 6.350.2 ± 5.129 ± 3
n87795
DMO58.9 ± 4.248.8 ± 2.937.8 ± 2.938.2 ± 4.625.7 ± 2.3P < 0.0001P = 0.083P = 0.021
n85984
  • Data are means ± SE for n animals issued from two or three litters. CMO, control mother offspring; DMO, diabetic mother offspring. Two-way ANOVA with age and group effects. Comparisons are made between CMO and DMO at the same age (unpaired t test,

  • *

    * P < 0.05;

  • P < 0.01).