TABLE 3

Creatinine clearance and proteinuria

Age (months)
ANOVA
13691218AgeGroupInteraction
Creatinine clearance (ml/min)CMO0.76 ± 0.031.33 ± 0.042.21 ± 0.132.72 ± 0.203.02 ± 0.232.99 ± 0.27
n556664
DMO0.76 ± 0.121.21 ± 0.101.66 ± 0.08*1.75 ± 0.062.20 ± 0.182.04 ± 0.22P < 0.0001P < 0.001P = 0.0069
n646454
Proteinuria (mg/day)CMO4.52 ± 0.3111.0 ± 0.4512.5 ± 1.2014.8 ± 2.0818.3 ± 2.7526.5 ± 2.53
n556664
DMO4.77 ± 0.8214.7 ± 0.04*18.4 ± 1.3423.3 ± 3.9215.3 ± 1.5557.2 ± 24.4P < 0.0001P = 0.0112P = 0.054
n646454
  • Data are means ± SE of n rats issued from two or three litters. CMO, control mother offspring; DMO, diabetic mother offspring. Two-way ANOVA with age and group effects. Comparisons are made between CMO and DMO at the same age (unpaired t test,

  • *

    * P < 0.001;

  • P < 0.01;

  • P < 0.05).