TABLE 2

Clinical characteristics and concordance within sibships (intraclass correlations) for the siblings with type 1 diabetes

Variablen (396)Mean ± SDRangeICC (95% CI)
Age at onset (years)38714.3 ± 10.20.2–40.00.15 (0.02–0.21)
Duration of diabetes at the latest ophthalmic examination (years)36925.9 ± 11.81.0–55.40.39 (0.26–0.45)
Difference of duration between probands and siblings (years)2.4 ± 1.3*
Current age (years)38740.2 ± 11.514.5–69.30.69 (0.61–0.73)
Age difference between proband and siblings (years)4.9 ± 1.2*
A1C (%)3808.5 ± 1.55.0–13.80.22 (0.09–0.29)
Systolic pressure (mmHg)378135 ± 1895–2150.20 (0.07–0.27)
Diastolic pressure (mmHg)37880 ± 950–1130.10 (−0.04 to 0.16)
MAP (mmHg)378100 ± 1272–1400.18 (0.04–0.25)
BMI (kg/m2)35425.3 ± 3.916.2–43.00.21 (0.07–0.28)
Total cholesterol (mmol/l)3414.9 ± 1.01.9–12.00.21 (0.06–0.30)
HDL cholesterol (mmol/l)3411.6 ± 0.520.2–4.30.33 (0.18–0.40)
Current smoking369Yes 86 (23%)0.15 (0.01–0.22)
No 83 (77%)
ETDRS score16940 (IQR 20–62)10–800.37 (0.24–0.43)
PDRYes 115 (31%)0.28 (0.14–0.35)
No 254 (69%)
Nephropathy status328Normoalbuminuria 202 (54%)0.26 (0.06–0.36)
Microalbuminuria 51 (14%)
Macroalbuminuria 50 (14%)
End-stage renal disease 25 (7%)
  • Data are

  • *

    * SE or

  • median value (188 sibships, men/women 202/167) unless otherwise indicated. MAP, mean arterial pressure; PDR, proliferative retinopathy.