TABLE 1

Relative changes of indicated proteins in total islet extracts in exendin-4–treated (5d) C57Bl/6 mice normalized to vehicle-treated controls and CBP-S436A normalized to wild-type littermate islet extracts

ProteinExendin-4 versus PBSP valueCBP-S436A+/− versus wild typeP value
Cyclin A22.69 ± 0.17<0.052.02 ± 0.20<0.05
Cyclin B10.90 ± 0.20NS0.59 ± 0.16NS
Cyclin B20.87 ± 0.31NS1.05 ± 0.31NS
Cyclin D11.26 ± 0.06NS0.86 ± 0.15NS
Cyclin D21.00 ± 0.09NS0.98 ± 0.31NS
Cyclin D31.11 ± 0.12NS0.85 ± 0.03NS
FoxO10.79 ± 0.050.050.98 ± 0.20NS
p27Not detected<0.05Not detected<0.05
Skp25.01 ± 0.98<0.050.80 ± 0.21NS
PDX-11.93 ± 0.20<0.050.85 ± 0.03NS
  • Data are means ± SE; n = 4 for each parameter and group. A significant difference (P < 0.05) from the corresponding control is indicated. For details, see text.