TABLE 2

Plasma glycerol, lactate, ß-hydroxybutyrate, NEFA, and alanine levels during the basal period and the final 30 min of hyperinsulinemic-hypoglycemic clamp studies in nondiabetic individualsbefore and after 6 weeks of fluoxetine treatment or placebo

Basal periodFinal 30 min
Glycerol (mmol/l)
    Pretreatment50 ± 362 ± 6
    Postfluoxetine64 ± 982 ± 11*
    Postplacebo90 ± 21100 ± 23
Lactate (mmol/l)
    Pretreatment0.5 ± 0.071.3 ± 0.08
    Postfluoxetine0.6 ± 0.091.8 ± 0.2*
    Postplacebo0.5 ± 0.131.1 ± 0.09
ß-Hydroxybutyrate (μmol/l)
    Pretreatment0.03 ± 0.010.015 ± 0.01
    Postfluoxetine0.06 ± 0.020.027 ± 0.01*
    Postplacebo0.095 ± 0.040.017 ± 0.01
NEFA (μmol/l)
    Pretreatment390 ± 53114 ± 13
    Postfluoxetine332 ± 45141 ± 22
    Postplacebo308 ± 8795 ± 20
Alanine (μmol/l)
    Pretreatment0.22 ± 0.030.21 ± 0.01
    Postfluoxetine0.24 ± 0.020.24 ± 0.02
    Postplacebo0.26 ± 0.050.24 ± 0.03
  • Data are means ± SE.

  • *

    * A significantly increased response during the final 30 min of hypoglycemia following 6 weeks of fluoxetine administration (*P < 0.05).