TABLE 3

Cardiovascular responses during hyperinsulinemic-hypoglycemic clamp studies in nondiabetic individuals before and after 6 weeks of fluoxetine or placebo

Basal periodFinal 30 min
Heart rate (beats/min)
    Pretreatment62 ± 369 ± 3
    Postfluoxetine62 ± 479 ± 6*
    Postplacebo59 ± 470 ± 5
Systolic blood pressure (mmHg)
    Pretreatment116 ± 3121 ± 5
    Postfluoxetine115 ± 4129 ± 6*
    Postplacebo111 ± 6118 ± 6
Diastolic blood pressure (mmHg)
    Pretreatment67 ± 261 ± 2
    Postfluoxetine69 ± 265 ± 2
    Postplacebo63 ± 259 ± 4
  • Data are means ± SE.

  • *

    * Significantly increased response during the final 30 min of hypoglycemia following 6 weeks of fluoxetine administration (*P < 0.05).