TABLE 1

Metabolic parameters of the groups at week 20

ParametersControl apoE−/−Diabetic apoE−/−Control RAGE−/−/apoE−/−Diabetic RAGE−/−/apoE−/−
n10101010
GHb (%)*3.8 ± 0.115.8 ± 0.74.5 ± 0.215.0 ± 0.4§
Body weight (g)*30.7 ± 0.424.5 ± 0.638.4 ± 1.127.7 ± 0.5§
Plasma glucose (mmol/l)11.3 ± 0.931.2 ± 1.29.6 ± 1.231.0 ± 1.9§
Total cholesterol (mmol/l)14.0 ± 1.125.6 ± 2.112.7 ± 0.621.1 ± 1.2§
HDL cholesterol (mmol/l)2.6 ± 0.23.1 ± 0.43.1 ± 0.24.0 ± 0.3§
LDL cholesterol (mmol/l)10.0 ± 1.021.6 ± 1.98.8 ± 0.416.5 ± 0.8§
Triglycerides (mmol/l)1.8 ± 0.32.1 ± 0.31.9 ± 0.41.4 ± 0.2
  • Data are means ± SE.

  • *

    * GHb and weight measurements performed in 24 animals/group.

  • P < 0.001 vs. control apoE−/− group;

  • P < 0.05 vs. diabetic apoE−/− group;

  • §

    § P < 0.05 vs. control RAGE−/−/apoE−/−.