TABLE 1

Results on morohometric analysis, frequency of insulitis, and phenotypic analysis on three autopsied pancreata from patients with fulminant type 1 diabetes

Morphometric analysis
Frequency of insulitis
Phenotype of MNCs infiltrating islets
Islet volume (%)β-Cell volume (%)α-Cell volume (%)[% (n1/n2)]Macrophage (%)CD8+ T-cell (%)
Patient
    Case 10.460.0060.073100 (34/34)42.338.4
    Case 20.940.1290.350100 (39/39)38.534.2
    Case 30.390.0010.17495 (21/22)70.224.6
Mean value in patients0.60 ± 0.30*0.045 ± 0.0730.199 ± 0.14099 (94/95)50.3 ± 17.332.4 ± 7.1
Mean value in nondiabetic control subjects (n = 10)3.14 ± 1.852.233 ± 1.4310.300 ± 0.0790 (0/747)
  • Data are means ± SD, unless otherwise indicated. n1, number of the islets with insulitis; n2, number of the evaluated islets.

  • *P < 0.002;

  • P < 0.001.