TABLE 2

Insulin secretion in GPR40 wild-type and knockout during hyperglycemic clamps

Wild typeKnockout
Hyperglycemic clamp in 24-h–fasted mice
    AUCInsulin T0–60 min51.6 ± 9.624.9 ± 6.9*
    AIRMax (ng/ml) T61 min5.7 ± 1.32.1 ± 0.6*
    GIR (mg · kg−1 · min−1)16 ± 510.5 ± 1
Hyperglycemic clamp in fed mice
    AUCInsulin T0–60 min65.4 ± 17.219.3 ± 6.9*
    AIRMax (ng/ml) T61 min11.8 ± 1.93.9 ± 0.5
    GIR (mg · kg−1 · min−1)71 ± 9§39 ± 4§
  • Data are means ± SE. n = 7–9 mice/group.

  • *P < 0.05;

  • P < 0.01 vs. wild type.

  • §P < 0.01 vs. fasted. AIR Max, maximal arginine-induced insulin response; AUCInsulin, area under the curve of insulin; GIR, glucose infusion rate.