TABLE 1

Associations of the SNP rs738409 in PNPLA3 with demographic and metabolic characteristics

CharacteristicsCC (Ile/Ile)CG (Ile/Met)GG (Met/Met)P (additive model)P (dominant model)
n18811131
Sex (female/male)115/7365/4620/110.81*0.81*
Age (years)45 ± 146 ± 145 ± 20.760.56
Body weight (kg)87.6 ± 1.385.1 ± 1.683.7 ± 2.80.220.08
BMI (kg/m2)29.9 ± 0.429.1 ± 0.428.7 ± 0.80.270.11
Waist circumference (cm)97.2 ± 0.9696.3 ± 1.293.1 ± 2.40.210.15
Total body fat (kg)26.8 ± 0.825.4 ± 1.024.9 ± 1.70.450.21
Visceral fat (kg)3.03 ± 0.132.90 ± 0.172.66 ± 0.290.340.14
Liver fat (%)5.40 ± 0.485.95 ± 0.567.18 ± 1.210.0010.005
Fatty liver (liver fat >5.56%)27% (n = 51)37% (n = 41)42% (n = 13)0.0270.011
Fasting glucose (mmol/l)5.29 ± 0.045.26 ± 0.055.12 ± 0.090.210.18
2-h glucose (mmol/l)7.07 ± 0.147.09 ± 0.197.01 ± 0.310.980.83
Fasting insulin (pmol/l)65 ± 460 ± 355 ± 60.810.97
2-h insulin (pmol/l)513 ± 30467 ± 33527 ± 730.740.67
Insulin sensitivity OGTT (arbitrary unit)12.60 ± 0.5112.91 ± 0.6612.88 ± 1.170.960.78
ISI clamp (μmol · kg−1 · min−1 · pM−1)0.065 ± 0.0030.065 ± 0.0050.061 ± 0.0060.470.34
ALT (U/l)29.3 ± 1.727.8 ± 1.229.1 ± 2.20.440.27
AST (U/l)25.0 ± 0.925.0 ± 0.823.4 ± 0.90.890.78
hs-CRP0.25 ± 0.030.25 ± 0.030.13 ± 0.020.180.91
Fetuin-A (μg/ml)272 ± 4266 ± 5266 ± 90.710.41
  • Values represent means ± SE. For statistical analyses, nonnormally distributed parameters were log transformed. The genotype effect was tested using an additive and a dominant model. Body weight, BMI, waist circumference, and total body fat were adjusted for age and sex. The other parameters were additionally adjusted for total body fat.

  • 2 test. ISI, insulin sensitivity index,

  • †available in 222 control subjects (C/C n = 124; C/G n = 72; T/T n = 26).