TABLE 2

Placental stereology of mothers with type 1 diabetes versus control mothers

Control mothersMothers withtype 1 diabetesP*
n3988
Volume fractions
    Intervillous space volume fraction (cm2 × cm3)0.4 ± 0.10.4 ± 0.100.06
    Villous volume fraction (cm2 × cm3)0.4 ± 0.10.4 ± 0.10.83
    Nonparenchymal volume fraction (cm2 × cm3)0.2 ± 0.10.2 ± 0.10.58
    Trophoblast volume fraction (cm2 × cm3)0.2 ± 0.00.2 ± 0.00.01
    Capillary volume fraction (cm2 × cm3)0.1 ± 0.00.1 ± 0.00.28
Compartment volumes
    Intervillous space volume (cm3)216.7 ± 65.2250.3 ± 81.20.02
    Villous volume (intermediate + terminal villi) (cm3)217 ± 70.3231.6 ± 95.80.39
    Nonparenchymal (stroma + fibrin) (cm3)130.2 ± 59.6131.9 ± 65.10.90
    Trophoblast volume (cm3)49.7 ± 20.048.1 ± 23.30.72
    Capillary volume (cm3)24.3 ± 16.227.9 ± 19.90.32
Surface areas
    Villous surface area (m2)4.0 ± 7.212.7 ± 6.80.34
    Capillary surface area (m2)14.4 ± 9.113.7 ± 9.70.73
    Villous membrane thickness (μm)9.3 ± 1.29.2 ± 1.00.59
    Morphometric diffusing capacity (cm2 · min−1 · kPa−1)2.7 ± 1.62.5 ± 1.60.50
    Morphometric diffusing capacity per birth weight (cm2 · min−1 · kPa−1 · kg−1)0.8 ± 0.40.7 ± 0.40.30
Isomorphic change
    Villous coefficient (cm3/cm3)239,317 ± 125,212192,225 ± 99,8270.025
    Intervillous space coefficient (cm3/cm3)275,676 ± 215,189220,532 ± 192,7950.154
Capillary surface area relative to villous volume250,770 ± 172,032219,690 ± 177,9860.36
    Capillary surface area relative to capillary volume2,338,266 ± 1,033,0811,854,403 ± 921,9060.010
    Capillary volume relative to villous volume0.1 ± 0.040.1 ± 0.00.28
    Villous elaboration index3,759 ± 1,2123,226 ± 1,1380.019
  • Data are means ± SD.

  • *P = value of significance in unpaired t test.