TABLE 3

Multivariate analysis of independent correlates of placental structure in OT1DM and control subjects

Control mothers
Mothers with type 1 diabetes
Associateβ ± SEPVariance (%)Associateβ ± SEPVariance (%)
Intervillous space volumeIGF-I5.8 ± 3.30.098.4IGF-I9.8 ± 2.8<0.00122.6
Leptin35.7 ± 15.30.022
Adiponectin−2.2 ± 1.30.081
Villous volumeIGF-I14.4 ± 3.3<0.00118.6
Nonparenchymal
    (stroma + fibrin)Mode of delivery14.7 ± 5.50.0097.9
Trophoblast volumeMode of delivery−5.1 ± 2.50.0518.4IGF-I2.5 ± 0.80.0059.3
Adiponectin−1.1 ± 0.60.10
Capillary volumeLeptin10.7 ± 6.30.107.8IGF-I2.1 ± 0.70.0059.0
Villous surface areaIGF-I0.6 ± 0.30.0216.3
Capillary surface areaLeptin6.5 ± 3.60.088.8Insulin5.2 ± 2.10.0176.7
Villous membrane
    thicknessMode of delivery−0.3 ± 0.20.0610.0
Theoretical diffusing capacityIGF-I0.15 ± 0.060.0127.4
Capillary surface area relative to villous volumeInsulin74,051 ± 39,6560.064.0
Capillary surface area relative to capillary
    volumeMode of delivery−161,606 ± 87,2570.068
Insulin560,045 ± 238,0330.021
Leptin−334,678 ± 200,0580.0988.1
  • Stepwise regression with log(insulin), log(leptin), adiponectin, IGF-I, mode of delivery, and sex was performed with an α of P ≤ 0.1 for adding or removing predictors from the model. Variance (%) explained by the model.