TABLE 1

Influence of dRK6 on physiologic and biochemical parameters and serum lipid profiles in db/db and db/m mice

db/mdb/m-RK6db/dbdb/db-RK6
Body weight (g)31.6 ± 1.231.2 ± 1.350.3 ± 5.8*42.4 ± 5.9*
Heart weight (g)0.12 ± 0.040.11 ± 0.050.12 ± 0.040.14 ± 0.05
Mean SBP (mmHg)95.6 ± 5.497.6 ± 3.599.1 ± 6.2102.3 ± 5.0
Hematocrit (%)34.0 ± 2.935.6 ± 3.439.8 ± 5.238.6 ± 6.4
Glucose (mmol/l)11.2 ± 1.111.8 ± 1.958.0 ± 5.957.6 ± 7.8
A1C (%)4.3 ± 0.24.1 ± 0.312.7 ± 1.213.6 ± 1.0
Total cholesterol (mmol/l)1.66 ± 0.381.53 ± 0.342.08 ± 0.371.92 ± 0.31
Triglycerides (mg/dl)60 ± 1666 ± 20103 ± 27114 ± 21
FFAs (mEq/l)1.45 ± 0.341.57 ± 0.553.18 ± 1.033.76 ± 1.19
Insulin (pg/ml)0.17 ± 0.130.19 ± 0.140.50 ± 0.140.33 ± 0.21
Serum VEGF (pg/ml)1.25 ± 1.7323.5 ± 7.7§6.6 ± 3.929.6 ± 8.5§
  • Data are means ± SD.

  • *P < 0.01,

  • P < 0.001,

  • P < 0.05 vs. dm and dm-dRK6.

  • §P < 0.001 vs. dm and P < 0.05 vs. db/db.