TABLE 1

Baseline clinical characteristics of the GoKinD collection

GoKinD collection
P
Control subjectsCase subjects
n885820
Men/women363/522423/397<0.0001
Age at type 1 diabetes diagnosis (years)12.9 ± 7.411.8 ± 6.70.0008
Duration of type 1 diabetes (years)*25.4 ± 7.826.5 ± 7.70.003
Age at examination (years)38.3 ± 8.743.1 ± 6.9<0.0001
Laser treatment (%)1785<0.0001
A1C (%)7.4 ± 1.28.3 ± 1.6<0.0001
ACR (μg/mg)
    Control subjects6.5 ± 3.7
    Proteinuric subjects1,520 ± 1,478
Systolic blood pressure (mmHg)117.6 ± 11.9131.1 ± 18.9<0.0001
Diastolic blood pressure (mmHg)71.4 ± 7.874.3 ± 10.8<0.0001
Case subjects with proteinuria/ESRD284/536
ESRD duration (years)7.3 ± 5.5
Kidney transplant (%)92
  • Data are means ±SD unless otherwise indicated.

  • *The duration of type 1 diabetes in control and proteinuric subjects is based on the duration at examination. Among ESRD case subjects, this is based on the duration of type 1 diabetes at the onset of ESRD. All other clinical characteristics are based on measurements performed at examination.

  • †Mean A1C values do not include data from case subjects that have undergone pancreas transplantation (32%).

  • ‡Percentages are of ESRD group.