TABLE 2

Summary of association results for ELMO1 SNPs in the GoKinD collection (P < 0.05)

SNPPositionLocationRisk allele (nonrisk allele)GoKinD collection
Control vs. all case subjects
Control vs. proteinuric subjects
Control vs. ESRD subjects
Control subjects (n = 885)All case subjects (n = 820)POR (95% CI)POR (95% CI)POR (95% CI)
rs1025520836,825,1683' flanking regionG(A)0.490.530.041.15 (1.01–1.32)0.451.08 (0.89–1.31)0.031.18 (1.01–1.38)
rs778593436,868,104Intron 20C(T)0.430.484.4 × 1031.22 (1.06–1.40)0.771.03 (0.85–1.26)3.3 × 1041.33 (1.14–1.55)
rs778297936,871,575Intron 20A(C)0.480.520.021.18 (1.03–1.35)0.371.09 (0.90–1.33)0.011.22 (1.04–1.42)
rs204180136,893,366Intron 18A(G)0.520.565.6 × 1031.22 (1.06–1.39)0.161.15 (0.95–1.40)6.2 × 1031.24 (1.06–1.45)
rs7799004*36,895,489Intron 17T(C)0.790.820.021.23 (1.04–1.46)0.171.19 (0.93–1.53)0.021.26 (1.03–1.53)
rs1176903836,909,839Intron 16T(G)0.510.561.7 × 1031.24 (1.09–1.42)0.071.20 (0.98–1.46)2.9 × 1031.27 (1.08–1.48)
rs188208036,922,366Intron 16A(G)0.520.563.2 × 1031.23 (1.08–1.41)0.121.17 (0.96–1.43)4.0 × 1031.26 (1.08–1.47)
rs1026831936,937,360Intron 16C(T)0.530.570.031.17 (1.02–1.34)0.251.12 (0.92–1.37)0.031.19 (1.02–1.39)
  • The most strongly associated ELMO1 SNPs (P < 0.05) in the GoKinD collection are presented for all case, proteinuric, and ESRD subjects. P values and ORs (95% CIs) for all case, proteinuric, and ESRD subjects vs. control subjects were calculated using stratified additive tests of association using the Cochran-Mantel-Haenszel method, adjusting for both sex and JDC/GWU strata. SNP positions and locations are in reference to NCBI Build 36.1.

  • *rs7799004 also reported by Shimazaki et al. (10).