TABLE 2

Genomic context and association test results for the three SNPs associated with fasting blood glucose levels among Indian Asians in the Hap610 sample at P < 5 × 10−8

Genomic context
Alleles
Risk allele frequency
Indian Asians
European Caucasians
Hap610 sample
Hap300 sample
Combined analysis
SNPChrGene locusAltRiskIAECEffectPEffectPPEffectP
rs216670611MTNR1BAG46.245.00.07 (0.04–0.09)1.6 × 10−80.05 (0.01–0.08)0.0062.1 × 10−90.05 (0.03–0.07)4.9 × 10−7
rs384755411MTNR1BGA49.849.40.06 (0.04–0.09)1.9 × 10−80.04 (0.01–0.08)0.013.9 × 10−90.06 (0.04–0.08)2.5 × 10−8
rs138715311MTNR1BGA38.135.30.06 (0.04–0.09)3.5 × 10−80.05 (0.01–0.08)0.011.5 × 10−80.05 (0.03–0.07)2.6 × 10−7
  • Data are effect size (95% CI) for fasting glucose in millimoles per liter for each copy of the risk allele. All three SNPs were directly genotyped, with call rates >99% in the three study samples. Alt, alternate allele; Chr, chromosome; EC, European Caucasian; IA, Indian Asian.