TABLE 3

Associations of rs2166706 with secondary phenotypes among Indian Asians in the Hap300 sample and European Caucasians

Indian AsiansPEuropean CaucasiansPPhetero
Type 2 diabetes1.21 (1.06–1.38)0.006
A1C (%)*0.12 (0.04–0.19)0.003
HOMA-B*−7.1 (−11.0 to −3.0)0.001−1.9 (−3.6 to −0.2)0.030.02
HOMA-S*5.4 (−4.5 to 16.2)0.293.5 (−0.7 to 7.9)0.100.74
BMI (kg/m2)*−0.17 (−0.40 to 0.06)0.14−0.36 (−0.80 to 0.08)0.110.45
Waist-to-hip ratio*−0.001 (−0.005 to 0.003)0.64−0.005 (−0.013 to 0.002)0.160.36
Hypertension0.93 (0.82–1.05)0.221.00 (0.95–1.06)0.720.28
Systolic blood pressure (mmHg)*−0.9 (−1.9 to 0.12)0.08−0.2 (−1.6 to 1.2)0.790.43
Diastolic blood pressure (mmHg)*−0.6 (−1.3 to 0.0)0.050.0 (−1.2 to 1.2)0.990.39
Cholesterol (mmol/l)*0.00 (−0.05 to 0.06)0.880.02 (−0.09 to 0.13)0.690.75
HDL cholesterol (mmol/l)*−0.2 (−1.5 to 1.1)0.781.4 (−1.1 to 3.9)0.280.27
Triglycerides (mmol/l)*5.1 (−1.0 to 11.7)0.10−2.1 (−7.0 to 3.1)0.430.08
  • Effects are *unit change (initial to final quantity) or †odds ratio (95% CI) per allele copy, under additive genetic model, adjusted for sex (and age among Indian Asians).