TABLE 3

Association of parental obesity status with offspring biomarkers

Log-biomarkerMutivariable-adjusted model
β (SE)P
CRP
    One parent with obesity0.01 (0.04)0.76
    Two parents with obesity0.16 (0.08)0.039
Aldosterone
    One parent with obesity−0.05 (0.03)0.14
    Two parents with obesity−0.03 (0.06)0.58
Renin
    One parent with obesity0.11 (0.06)0.037
    Two parents with obesity0.15 (0.09)0.091
BNP
    One parent with obesity0.08 (0.05)0.13
    Two parents with obesity−0.007 (0.08)0.93
NT-ANP
    One parent with obesity0.05 (0.03)0.10
    Two parents with obesity0.03 (0.05)0.52
Fibrinogen
    One parent with obesity0.001 (0.01)0.90
    Two parents with obesity−0.005 (0.02)0.81
PAI-1
    One parent with obesity−0.04 (0.03)0.23
    Two parents with obesity−0.09 (0.05)0.093
  • The regression coefficient (β) indicates the increase in log-biomarker per parent with obesity. Thus, having two parents with obesity was associated with an eβ = e0.16 = 1.17-fold increase in multivariable-adjusted CRP levels relative to those with no parents with obesity. Multivariable adjustment for age, sex, systolic and diastolic blood pressure, antihypertensive treatment, total-to-HDL cholesterol ratio, smoking, diabetes, and BMI.