TABLE 1

Metabolic parameters of GPR40 wild-type and knockout mice and β-cell mass

Wild typeKnockout
Basal 24-h–fasted mice
    Body weight (g)24.1 ± 0.225.1 ± 0.5
    Basal glycemia (mg/dl)120 ± 5119 ± 9
    Free fatty acids (mmol/l)0.50 ± 0.030.55 ± 0.03
    Basal insulinemia (ng/ml)0.06 ± 0.010.08 ± 0.01
    C-peptide (ng/ml)0.51 ± 0.040.49 ± 0.01
Basal fed mice
    Body weight (g)28.2 ± 0.9*27.8 ± 0.5*
    Basal glycemia (mg/dl)151 ± 3154 ± 5
    Free fatty acids (mmol/l)0.09 ± 0.010.11 ± 0.02
    Basal insulinemia (ng/ml)0.48 ± 0.010.51 ± 0.03
    C-peptide (ng/ml)0.64 ± 0.03*0.71 ± 0.02*
β-Cell mass (mg)1.55 ± 0.092 ± 0.22
Fat (% of body weight)12 ± 110 ± 1
  • Data are means ± SE. n = 7–9 mice/group.

  • *P < 0.05;

  • P < 0.01 vs. fasted.