TABLE 2

Physical and metabolic parameters of cGK-Tg mice fed on standard chow or high-fat diet

Standard chow
High-fat diet
Wild typecGK-TgWild typecGK-Tg
Body weight (g)
    18 weeks old32.0 ± 0.627.6 ± 0.4*43.9 ± 1.235.7 ± 1.4*
Glucose (mg/dl)
    Ad libitum feeding160.7 ± 6.0137.7 ± 5.1*233.5 ± 17.1174.0 ± 7.7*
    24-h fasting93.5 ± 4.778.8 ± 2.3113.5 ± 7.689.8 ± 3.7
Insulin (ng/dl)
    Ad libitum feeding1.4 ± 0.20.8 ± 0.29.1 ± 1.03.5 ± 0.6*
    24-h fasting0.26 ± 0.050.23 ± 0.030.95 ± 0.220.41 ± 0.05
Triglyceride (mg/dl)
    Ad libitum feeding103.3 ± 10.189.2 ± 7.0134.9 ± 11.5134.9 ± 15.8
    24-h fasting84.3 ± 6.881.6 ± 6.9112.8 ± 9.5103.4 ± 11.6
Fatty acid (mEq/l)
    Ad libitum feeding1.04 ± 0.050.84 ± 0.101.32 ± 0.181.08 ± 0.11
    24-h fasting1.69 ± 0.091.86 ± 0.081.66 ± 0.092.22 ± 0.08*
Epinephrine (ng/day)
    Urinary excretion48.2 ± 9.352.7 ± 12.849.6 ± 6.340.5 ± 6.1
Norepinephrine (ng/day)
    Urinary excretion312.3 ± 62.2312.3 ± 97.4547.7 ± 62.2570.3 ± 47.6
  • *P < 0.01,

  • P < 0.05 compared with wild type on the same feeding condition.