TABLE 1

ROS, GSH, and HNE content in hippocampi homogenates from nondiabetic or diabetic rats exposed to 30-min ischemia and 1-h reperfusion without or with drug treatment

ROS (units fluorescence/mg protein)GSH (μg/mg protein)HNE (μmol/l)
Sham89.5 ± 10.49*57.08 ± 0.970.24 ± 0.16*
STZ150.3 ± 9.5037.07 ± 5.683.90 ± 0.21*
I/R141.7 ± 8.5239.67 ± 6.034.8 ± 0.3
STZ I/R198.7 ± 16.6532.67 ± 6.035.65 ± 0.26
STZ I/R + INS (2 IU/kg)147.3 ± 18.7944.89 ± 8.543.20 ± 0.34*
STZ I/R + TDZD-8 (3 mg/kg)133.8 ± 25.11*47.10 ± 10.683.29 ± 0.46*
  • Data are means ± SE of five animals/group.

  • * P < 0.05 vs. STZ I/R.