TABLE 1

Plasma free fatty acid levels; arterial blood lactate, alanine, and glycerol levels; and net hepatic balance in 18-h–fasted conscious dogs during the basal (−40 to 0 min) and experimental (0–240 min) periods

Basal periodExperimental period (min)
−40 to 060120180210240
Plasma free fatty acid level (μmol/l)
    Control924 ± 69245 ± 54117 ± 23115 ± 27147 ± 48124 ± 39
    Vildagliptin736 ± 118*111 ± 2388 ± 2671 ± 2582 ± 3166 ± 15
Blood glycerol level (μmol/l)
    Control97 ± 642 ± 928 ± 431 ± 535 ± 632 ± 6
    Vildagliptin70 ± 9*21 ± 4*24 ± 420 ± 519 ± 416 ± 2
Net hepatic glycerol uptake (μmol · kg−1 · min−1)
    Control1.7 ± 0.10.8 ± 0.20.5 ± 0.10.6 ± 0.20.6 ± 0.20.6 ± 0.2
    Vildagliptin1.6 ± 0.30.5 ± 0.20.5 ± 0.10.4 ± 0.20.5 ± 0.20.3 ± 0.1
Blood lactate level (μmol/l)
    Control482 ± 81534 ± 71536 ± 89545 ± 66593 ± 72564 ± 59
    Vildagliptin433 ± 87571 ± 82535 ± 83555 ± 63543 ± 49551 ± 68
Net hepatic lactate balance (μmol · kg−1 · min−1)
    Control−4.5 ± 0.72.4 ± 1.71.1 ± 0.80.3 ± 1.20.7 ± 0.91.5 ± 1.1
    Vildagliptin−2.3 ± 2.75.4 ± 2.42.1 ± 1.63.2 ± 1.72.5 ± 1.73.2 ± 1.9
Blood alanine level (μmol/l)
    Control289 ± 24261 ± 23239 ± 16230 ± 14235 ± 16225 ± 15
    Vildagliptin300 ± 33275 ± 24245 ± 13217 ± 18221 ± 21219 ± 24
Net hepatic alanine uptake (μmol · kg−1 · min−1)
    Control2.2 ± 0.21.5 ± 0.21.7 ± 0.12.1 ± 0.22.0 ± 0.12.2 ± 0.3
    Vildagliptin2.3 ± 0.41.8 ± 0.22.0 ± 0.52.2 ± 0.22.4 ± 0.22.5 ± 0.3
  • Data are means ± SE; n = 6 per group;

  • * P < 0.05.