TABLE 3

Ordered subset analyses (ΔP < 0.05) of age at diagnosis and BMI

ChromosomeLinked subsetFlanking markersPosition (cM)Entire sample LODMaximum LODOptimal subsetRemaining familiesEmpirical P value for changeProportion of pedigrees
3Early age diagnosisrs1512532/rs1398748120.01.522.9339.43 ± 8.1956.00 ± 5.480.04190.73
4High BMIrs1456860/rs145090075.80.122.7239.35 ± 3.7030.56 ± 3.140.01670.36
7Early age diagnosisrs1105305/rs51725878.01.643.9336.54 ± 7.7052.40 ± 6.000.00520.54
9High BMIrs994367/rs56076453.00.022.3039.47 ± 3.6930.64 ± 3.180.01490.35
9Early age diagnosisrs2026406/rs92763271.50.541.8437.92 ± 7.9353.81 ± 5.830.03210.62
9Late age diagnosisrs1819730/rs1407850110.002.7662.42 ± 4.4042.16 ± 9.190.04860.09
12High BMIrs617022/rs155877615.00.622.8437.08 ± 4.0328.67 ± 2.390.01760.60
14Late age diagnosisrs1547350/rs6644123.12.064.0550.37 ± 6.4033.74 ± 7.300.00690.61
16Low BMIrs870856/rs869048131.10.071.9526.07 ± 1.7535.05 ± 4.650.02470.15
17Low BMIrs12939286/rs110625.50.092.7827.43 ± 2.1035.89 ± 4.380.00490.26
18Early age diagnosisrs1517162/rs56597391.00.093.8127.04 ± 6.4847.22 ± 7.640.00740.16
  • Data are means ± SD.