TABLE 5

Relationship between cord serum C-peptide and neonatal anthropometrics

Cord serum C-peptide (μg/l)nNo. with outcomeModel IModel II
Birth weight >90th percentile*
    ≤0.52,911131 (4.5)1.001.00
    0.6–0.86,530392 (6.0)1.36 (1.11–1.66)1.26 (1.03–1.55)
    0.9–1.25,899614 (10.4)2.47 (2.03–2.99)2.21 (1.82–2.70)
    1.3–1.52,077283 (13.6)3.35 (2.70–4.15)2.89 (2.32–3.60)
    1.6–2.11,639333 (20.3)5.41 (4.37–6.69)4.68 (3.77–5.82)
    2.2–3.0571140 (24.5)6.89 (5.32–8.93)5.62 (4.31–7.33)
    ≥3.124262 (25.6)7.31 (5.21–10.25)6.72 (4.75–9.51)
    Total19,8691,955 (9.8)
Sum of skin folds >90th percentile*
    ≤0.52,412117 (4.9)1.001.00
    0.6–0.85,647369 (6.5)1.37 (1.11–1.70)1.27 (1.03–1.58)
    0.9–1.25,145513 (10.0)2.17 (1.77–2.67)1.92 (1.56–2.37)
    1.3–1.51,821267 (14.7)3.37 (2.69–4.23)2.84 (2.26–3.57)
    1.6–2.11,409265 (18.8)4.54 (3.61–5.71)3.74 (2.97–4.72)
    2.2–3.0485101 (20.8)5.16 (3.87–6.88)4.00 (2.99–5.36)
    ≥3.118146 (25.4)6.68 (4.56–9.80)5.57 (3.78–8.21)
    Total17,1001,678 (9.8)
Percent body fat >90th percentile*
    ≤0.52,399119 (5.0)1.001.00
    0.6–0.85,630370 (6.6)1.35 (1.09–1.67)1.24 (1.00–1.54)
    0.9–1.25,140513 (10.0)2.12 (1.73–2.61)1.87 (1.52–2.31)
    1.3–1.51,817276 (15.2)3.43 (2.74–4.30)2.88 (2.30–3.62)
    1.6–2.11,403269 (19.2)4.54 (3.62–5.70)3.77 (2.99–4.75)
    2.2–3.0485121 (25.2)6.46 (4.90–8.51)5.02 (3.79–6.66)
    ≥3.118143 (23.8)5.97 (4.05–8.81)5.06 (3.41–7.52)
    Total17,0501,726 (10.0)
  • Data are n (%) or OR (95% CI). n = total number in the cord C-peptide category (excluding births with gestational age <30 weeks and fetal deaths); No. with outcome = number in the cord C-peptide category with the outcome (% proportion in the cord C-peptide category with the outcome). Model I, adjusted for the variables used in estimating 90th percentiles; model II, adjusted for age, BMI, BMI2, height, mean arterial blood pressure, gestational age at the OGTT, smoking, alcohol use, hospitalization prior to delivery, and any family history of diabetes.

  • *

    * Defined based on sex, ethnicity, field center, gestational age (36–44 weeks for skin folds and body fat), and parity.