TABLE 1

Clinical and biological characteristics of insulin secretion in our young obese Caucasian cohort, according to rs573225 variant

G/GG/AA/A
n60293381
Age (years)12.4 ± 2.811.8 ± 311.7 ± 2.8
BMI (kg/m2)30.7 ± 5.629.7 ± 5.329.6 ± 5.5
Fasting glucose (mmol/l)4.41 ± 0.51*4.53 ± 0.534.56 ± 0.57
Glycemia at 30 min (mmol/l)7.47 ± 1.227.67 ± 1.237.53 ± 1.3
Fasting insulin (μU/ml)15 ± 7.715.7 ± 8.715.9 ± 9.9
Insulin at 30 min (μU/ml)87 ± 52109 ± 77106 ± 85
IGI21 ± 16.933.5 ± 24.236.8 ± 38.1
HOMA-β68.5 ± 34.169.6 ± 38.869.9 ± 41.4
  • Data are means ± SD. P values under a recessive model:

  • *

    * P = 0.032 and P = 0.037 under an additive model,

  • P = 0.0191 under a recessive model, and P = 0.0102 under an additive model.