TABLE 2

Association of candidate SNPs with plasma insulin levels in the general population sample

Gene (rs number)Risk allele (T)Plasma insulin (μU/ml)
P
TTTGGGANOVAMultivariate
TCF7L2* (rs12255372)
    Control5.5 ± 2.7(2)6.2 ± 4.7(52)6.5 ± 4.8(1,770)0.6610.749
    Type 2 diabetes(0)4.2 ± 1.0(3)9.0 ± 7.3(136)0.2560.368
TCF7L2* (rs7903146)TTTTCCC
    Control6.8(1)6.5 ± 4.3(111)6.5 ± 4.8(1,712)0.9670.336
    Type 2 diabetes(0)5.1 ± 2.3(8)9.1 ± 7.4(131)0.1300.226
CDKAL1 (rs7756992)GGGGAAA
    Control6.3 ± 5.2(428)6.5 ± 4.6(895)6.6 ± 4.7(501)0.2270.457
    Type 2 diabetes7.9 ± 7.0(38)8.8 ± 6.3(75)10.7 ± 10.0(26)0.2690.020
CDKAL1 (rs7754840)CCCCGGG
    Control6.1 ± 4.7(315)6.4 ± 4.8(868)6.7 ± 4.7(641)0.0830.157
    Type 2 diabetes7.1 ± 5.1(32)9.0 ± 6.5(67)10.3 ± 9.4(40)0.1540.097
HHEX (rs1111875)CCCCTTT
    Control6.4 ± 4.6(185)6.4 ± 4.4(755)6.6 ± 5.1(884)0.8670.883
    Type 2 diabetes9.8 ± 11.6(15)7.7 ± 5.2(62)9.9 ± 7.7(62)0.3230.470
HHEX (rs7923837)GGGGAAA
    Control6.1 ± 4.1(112)6.5 ± 4.9(692)6.5 ± 4.7(1020)0.8180.749
    Type 2 diabetes7.3 ± 4.6(9)8.8 ± 6.9(56)9.1 ± 7.8(74)0.8110.789
IGF2BP2 (rs4402960)TTTTGGG
    Control6.2 ± 3.9(215)6.7 ± 5.2(767)6.3 ± 4.5(842)0.2760.308
    Type 2 diabetes12.2 ± 10.0(15)7.8 ± 5.4(72)9.5 ± 8.4(52)0.1860.843
IGF2BP2 (rs1470579)CCCCAAA
    Control6.1 ± 3.8(239)6.8 ± 5.2(781)6.3 ± 4.5(804)0.1180.314
    Type 2 diabetes11.6 ± 9.6(17)7.8 ± 5.4(72)9.5 ± 8.5(50)0.2760.869
CDKN2A/B (rs10811661)TTTTCCC
    Control6.4 ± 4.7(591)6.5 ± 4.6(886)6.6 ± 5.2(347)0.7190.858
    Type 2 diabetes8.1 ± 8.0(41)8.9 ± 6.5(72)10.2 ± 8.0(26)0.3460.169
SLC30A8 (rs13266634)CCCCTTT
    Control6.5 ± 4.9(671)6.4 ± 4.4(847)6.6 ± 5.2(306)0.9390.910
    Type 2 diabetes9.8 ± 7.1(51)7.9 ± 5.6(68)9.8 ± 11.5(20)0.1510.332
KCNJ11 (rs5219)TTTTCCC
    Control6.5 ± 4.8(222)6.3 ± 4.6(836)6.7 ± 4.9(766)0.0880.156
    Type 2 diabetes6.8 ± 3.8(28)8.8 ± 7.2(68)10.3 ± 8.7(43)0.1440.205
  • Data are means ± SD. n = 1,963. Number of subjects in each genotype is provided in parentheses. Statistical significance was assessed using log-transformed insulin value. Multiple regression analysis involving each genotype as an additive model adjusted for age, sex, and BMI.

  • *

    * T allele dominant model.