TABLE 2

Genotypic association with diabetic nephropathy and type 2 diabetes

Hardy-Weinberg equilibrium
Genotypic association
2 d.f.Dominant
Additive
Recessive
Case subjectsControl subjectsPPORCIPORCIPORCI
Diabetic nephropathy vs. nondiabetic
    Admixture0.0240.0600.00190.00151.371.13–1.670.03931.161.01–1.340.64420.940.71–1.24
    Age0.00320.00091.491.18–1.890.00811.261.06–1.490.62251.090.78–1.53
    BMI0.00080.00041.461.19–1.800.01101.221.05–1.420.93340.990.73–1.34
    Sex0.00170.00131.381.13–1.670.03781.161.01–1.340.63300.930.70–1.24
    Combined0.00191.461.15–1.860.01141.251.05–1.490.55931.110.79–1.56
Type 2 diabetes + diabetic nephropathy vs. nondiabetic
    Admixture0.0030.0610.00030.00031.401.17–1.670.01961.171.03–1.330.55490.920.71–1.20
    Age0.00060.00021.501.21–1.860.00581.251.07–1.460.87961.020.75–1.40
    BMI0.00010.00011.471.21–1.790.00751.221.05–1.410.74730.950.72–1.27
    Sex0.00020.00021.411.17–1.690.01871.171.03–1.340.51100.920.70–1.19
    Combined0.00051.481.19–1.840.00881.241.06–1.450.84081.030.75–1.42
  • Genotypic association for rs182052 after individual adjustment for admixture, age, BMI, and sex in 851 type 2 diabetes + diabetic nephropathy case subjects versus 871 nondiabetic control subjects and type 2 diabetes + diabetic nephropathy case subjects plus an additional 317 type 2 diabetic (no nephropathy) subjects (total cases = 1,168) versus the same 871 nondiabetic control subjects. Genotypic association is also shown for all four covariates simultaneously (combined).