TABLE 3

Genes involved in OXPHOS and citrate cycle, the two pathways that were upregulated in nondiabetic Asian Indians compared with nondiabetic European Americans

Probe setNondiabetic European AmericansNondiabetic Asian IndiansNondiabetic Asian Indians/nondiabetic European AmericansPAccessionGene name
Oxidative phosphorylation, P = 0.013
    NDUFB4218226_s_at7659.668172.121.0670.0151NM_004547NADH dehydrogenase (ubiquinone) 1 β subcomplex 4,
    COX8A201119_s_at4522.815004.641.1070.0259NM_004074Cytochrome c oxidase subunit 8A (ubiquitous)
    COX11239760_at95.54103.711.0850.0307AI198212COX11 homolog
    COX5A229426_at127.38152.441.1970.0354BF196691Cytochrome c oxidase subunit Va
    COX7C213846_at2179.922314.601.0620.0416AA382702Cytochrome c oxidase subunit VIIc
    ATP5G3228168_at321.71357.211.1100.0472AU153583ATP synthase, H + transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
    NDUFAB1202077_at3916.674256.751.0870.0478NM_005003NADH dehydrogenase (ubiquinone) 1, α/β subcomplex, 1,
Citrate cycle, P = 0.015
    SUCLA2202930_s_at1874.181999.181.0670.0442NM_003850Succinate-CoA ligase, ADP-forming, β-subunit
    IDH3G202471_s_at610.71663.921.0870.0454NM_004135Isocitrate dehydrogenase 3 (NAD+)-γ
    ATP5G3228168_at321.71357.211.1100.0472AU153583ATP synthase, H + transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
  • P values associated with each pathway were calculated by IPA. P values associated with each gene were calculated using paired t test.