TABLE 2

Evidence for linkage in regions previously reported to harbor IDDM loci

LocusChromosomeDefined by marker(s)Marker testedLODP
IDDM16p21.3HLA-DQβ1rs1019937213.28.0 × 10−216
IDDM211p15.5INS-VNTRrs10044463.090.00008
IDDM315q26D15S107rs9063100.000.6
IDDM411q13D11S1917rs9233460.870.02
IDDM56q25ESRrs119020.000.5
IDDM618qD18S64rs19434180.680.04
IDDM72q31D2S152rs6960921.910.002
IDDM86q27D6S264rs69101210.450.07
IDDM93q21-25D3S1303rs19833800.400.09
IDDM1010cenD10S193rs9596291.070.013
IDDM1114q24.3D14S67rs10129210.130.2
IDDM122q33CTLA4rs19479831.050.014
IDDM132q34IGFBP2rs18513280.630.04
IDDM156qD6S283rs22079585.99*7.5 × 10−8
IDDM1614q32.3D14S293rs8729450.050.3
IDDM1710q25D10S592rs1516030.160.2
IDDM185q33-34IL12Brs2706640.010.4
1q42D1S1617rs3428170.000.5
16q22-24D16S3098rs10379731.240.008
  • *Not corrected for allele sharing at IDDM1. Adjustment based upon the expected LOD at D6S283 and the recombination fraction with HLA yields an adjusted LOD of 2.7.