Pathogenesis of type 2 diabetes: implications for therapy

  • 1) Effective treatment of type 2 diabetes requires multiple drugs used in combination to correct multiple pathophysiological defects.

  • 2) Treatment should be based on known pathogenic abnormalities and not simply on reduction of A1C.

  • 3) Therapy must be started early in the natural history of type 2 diabetes to prevent progressive β-cell failure.