TABLE 3

HRs (95% CI) of 5-year mortality in people with type 2 diabetes of the Casale Monferrato Study

All-cause mortality
Cardiovascular mortality
Model 1Model 2Model 3Model 1Model 2Model 3
CRP tertiles (mg/dl)
    <1.61.001.001.001.001.001.00
    1.6–4.41.27 (1.00–1.62)1.27 (0.98–1.64)1.35 (0.98–1.87)1.18 (0.82–1.68)1.07 (0.73–1.56)1.22 (0.74–2.00)
    >4.41.99 (1.58–2.49)1.81 (1.41–2.32)1.65 (1.20–2.28)1.94 (1.39–2.71)1.62 (1.13–2.33)1.76 (1.09–2.82)
    P for trend<0.0001<0.0001<0.0001<0.00010.0060.015
CRP (mg/l)
    ≤3 mg/l1.001.001.001.001.001.00
    >3 mg/l1.64 (1.37–1.96)1.49 (1.22–1.82)1.51 (1.18–1.92)1.53 (1.17–1.99)1.32 (0.99–1.77)1.44 (0.99–2.08)
AER
    <20 μg/min1.001.00
    ≥20 μg/min1.47 (1.15–1.87)1.47 (1.01–2.14)
Hypertension1.02 (0.64–1.63)0.69 (0.36–1.34)
LDL cholesterol (1 SD)0.89 (0.79–1.01)1.07 (0.89–1.28)
HDL cholesterol (1 SD)0.99 (0.88–1.13)0.92 (0.76–1.12)
A1C (1 SD)1.10 (0.97–1.26)1.19 (0.97–1.44)
CVD1.70 (1.31–2.22)2.56 (1.74–3.76)
Antidiabetes treatment
    Diet1.001.00
    Oral drugs1.09 (0.76–1.57)1.24 (0.68–2.24)
    Insulin1.81 (1.12–2.94)2.29 (1.08–4.84)
Smoking
    Never1.001.00
    Former smoker1.34 (0.96–1.86)1.24 (0.74–2.06)
    Current smoker1.42 (0.94–2.15)0.74 (0.33–1.65)
Central obesity0.87 (0.67–1.12)0.92 (0.62–1.37)
Statins1.02 (0.75–1.37)1.31 (0.86–1.99)
  • Model 1: adjusted for age, sex, diabetes duration. Model 2: model 1 adjustments plus hypertension, LDL and HDL cholesterol, A1C, smoking status, CVD, diabetes treatment, waist circumference, and statins. Model 3: model 2 adjustments plus AER.