TABLE 1

Metabolic parameters in hGPR40 transgenic (47M and 23F) mice fed a regular diet or a high-fat diet

Body weight (g)Plasma glucose (mg/dl)Plasma insulin (ng/ml)Plasma NEFA (mEq/l)
Regular diet
    Fed
        Nontransgenic28.8 ± 0.4170.0 ± 4.11.54 ± 0.300.33 ± 0.08
        Transgenic(47M)27.5 ± 0.6153.6 ± 6.21.61 ± 0.430.24 ± 0.06
        Nontransgenic28.7 ± 0.4187.6 ± 9.81.43 ± 0.380.37 ± 0.08
        Transgenic (23F)28.1 ± 0.3161.4 ± 8.11.46 ± 0.380.41 ± 0.06
    Fasted
        Nontransgenic24.3 ± 0.4106.0 ± 4.80.19 ± 0.041.35 ± 0.06
        Transgenic (47M)22.9 ± 0.684.5 ± 4.4*0.23 ± 0.051.00 ± 0.07
        Nontransgenic24.0 ± 0.3117.7 ± 5.00.21 ± 0.031.07 ± 0.07
        Transgenic (23F)23.6 ± 0.389.9 ± 5.2*0.24 ± 0.050.98 ± 0.07
High-fat diet
    Fed
        Nontransgenic49.9 ± 0.7215.6 ± 8.118.87 ± 3.520.52 ± 0.04
        Transgenic (47M)49.6 ± 1.0212.8 ± 9.916.17 ± 2.950.49 ± 0.03
    Fasted
        Nontransgenic46.0 ± 0.6173.8 ± 5.62.88 ± 0.310.80 ± 0.04
        Transgenic (47M)45.4 ± 0.9133.3 ± 4.5*3.07 ± 0.390.80 ± 0.04
  • All parameters were measured in the fed and fasted states at 16 weeks of age on a regular diet. The hGPR40 transgenic (47M) and nontransgenic mice were fed a high-fat diet containing 60 kcal% fat for 12 weeks. All parameters were measured in the fed and fasted state at 20 weeks of age. All values are the means ± SE, n = 7–10 per genotype. *P ≤ 0.01 vs. nontransgenic mice by Student's t test.