Spearman correlation coefficients between surrogate indexes of β-cell function and insulin release during the first phase (0–10 min) and second phase (10–60 min) and total (0–60 min) during an IVGTT
β-Cell function indexes | Insulin release during an IVGTT | ||
---|---|---|---|
First phase | Second phase | Total | |
HOMA-β | 0.568 | 0.645 | 0.663 |
Insulinogenic index | 0.579 | 0.469 | 0.541 |
InsAUC30/GluAUC30 | 0.666 | 0.707 | 0.743 |
ΔInsAUC120/ΔGluAUC120 | 0.375 | 0.409 | 0.405 |
InsAUC120/GluAUC120 | 0.648 | 0.750 | 0.775 |
First-phase Stumvoll | 0.651 | 0.663 | 0.702 |
Second-phase Stumvoll | 0.662 | 0.692 | 0.730 |
Fasting insulin | 0.548 | 0.747 | 0.735 |
Insulin at 30 min of an OGTT | 0.615 | 0.691 | 0.715 |
Insulin at 120 min of an OGTT | 0.429 | 0.673 | 0.645 |
Insulin AUC during an OGTT | 0.558 | 0.770 | 0.776 |
P < 0.001 for all correlation coefficients. Indexes of β-cell function were calculated as described previously: HOMA-β(30), insulinogenic index (31), ΔInsAUC120/ΔGluAUC120 (25), InsAUC120/GluAUC120 (31), first phase Stumvoll (32), and second phase Stumvoll (32). InsAUC30/GluAUC30 = (insulin at 0 min + insulin at 30 min of an OGTT)/(glucose at 0 min + glucose at 30 min of an OGTT).