TABLE 2

Plasma lipids and insulin in 4-month-old male and female Mstn+/+, Mstn+/Ln, and MstnLn/Ln mice weaned on HFD or standard diet

Total cholesterol (mg/dl)HDL cholesterol (mg/dl)Triglycerides (mg/dl)FFAs (mmol/l)Insulin (ng/ml)
Males
    Mstn+/+ HFD291.5 ± 27.6124.6 ± 13.0118.5 ± 12.81.44 ± 0.192.82 ± 0.32
    Mstn+/− HFD231.0 ± 15.099.5 ± 4.0*107.5 ± 5.2*1.42 ± 0.04*2.99 ± 0.21*
    Mstn−/− HFD184.0 ± 13.9§86.9 ± 2.6§84.5 ± 3.01.40 ± 0.070.83 ± 0.08
    Mstn+/+ standard diet85.0 ± 6.244.0 ± 2.783.0 ± 6.00.88 ± 0.050.87 ± 0.44
    Mstn+/− standard diet100.7 ± 3.247.0 ± 1.784.4 ± 3.60.84 ± 0.051.05 ± 0.38
    Mstn−/− standard diet72.4 ± 4.749.3 ± 1.878.0 ± 4.41.23 ± 0.090.59 ± 0.07
Females
    Mstn+/+ HFD237.8 ± 30.888.2 ± 10.399.0 ± 15.51.42 ± 0.121.43 ± 0.22
    Mstn+/− HFD207.0 ± 13.276.1 ± 2.481.3 ± 4.91.28 ± 0.031.61 ± 0.20
    Mstn−/− HFD173.6 ± 17.1§79.9 ± 2.8§83.1 ± 4.91.41 ± 0.040.62 ± 0.05
    Mstn+/+ standard diet70.8 ± 4.529.3 ± 1.465.1 ± 2.00.72 ± 0.030.23 ± 0.06
    Mstn+/− standard diet69.8 ± 2.831.2 ± 0.969.1 ± 2.30.81 ± 0.040.19 ± 0.12
    Mstn−/− standard diet71.5 ± 7.339.4 ± 2.369.3 ± 3.41.16 ± 0.080.56 ± 0.02
  • Data are means ± SE.

  • *P < 0.05 vs. HFD Mstn+/Ln females;

  • P < 0.05 vs. HFD Mstn+/+;

  • P < 0.05 vs. HFD Mstn+/Ln;

  • §P < 0.05 vs. standard diet MstnLn/Ln mice.