TABLE 2

Genotypic means for quantitative measures of glucose homeostasis calculated in set 1 of the IRASFS Hispanic-American population

PhenotypeSNPAllelesMAFGenotypic means ± SD (n)*
P
1/11/22/2
SIrs1037257C/T0.372.37 ± 2.21 (207)1.96 ± 1.59 (280)2.13 ± 2.17 (85)0.027
rs4969076C/G0.222.13 ± 2.01 (315)2.05 ± 1.69 (198)2.24 ± 2.21 (30)0.98
rs1037260T/G0.132.09 ± 1.90 (470)2.25 ± 2.05 (94)2.18 ± 1.74 (5)0.40
rs11077670G/A0.142.09 ± 1.98 (398)2.22 ± 1.86 (139)2.01 ± 2.12 (8)0.91
rs1868486G/T0.302.23 ± 2.06 (254)2.10 ± 1.92 (232)1.81 ± 1.56 (73)0.0040
rs714925A/G0.302.19 ± 2.03 (244)2.07 ± 1.89 (243)1.76 ± 1.45 (71)0.011
rs998571A/G0.292.24 ± 2.01 (261)2.14 ± 1.97 (219)1.71 ± 1.43 (73)0.0040
rs7220818A/G0.371.93 ± 1.67 (216)2.11 ± 1.94 (268)2.71 ± 2.33 (91)0.0020
rs6501603T/G0.482.27 ± 2.16 (152)2.03 ± 1.86 (276)2.15 ± 1.72 (128)0.51
rs4969017T/C0.032.14 ± 1.97 (529)1.96 ± 1.13 (20)1.01 ± 0.00 (1)0.18
AIRrs1037257C/T0.37713 ± 543 (207)743 ± 619 (280)845 ± 721 (85)0.54
rs4969076C/G0.22788 ± 623 (315)698 ± 585 (198)820 ± 627 (30)0.29
rs1037260T/G0.13763 ± 644 (470)761 ± 566 (94)513 ± 177 (5)0.69
rs11077670G/A0.14770 ± 620 (398)676 ± 698 (139)920 ± 737 (8)0.17
rs1868486G/T0.30727 ± 532 (254)801 ± 706 (232)755 ± 696 (73)0.80
rs714925A/G0.30728 ± 532 (244)800 ± 699 (243)751 ± 708 (71)0.81
rs998571A/G0.29722 ± 525 (261)812 ± 724 (219)774 ± 699 (73)0.66
rs7220818A/G0.37788 ± 643 (216)739 ± 637 (268)736 ± 567 (91)0.66
rs6501603T/G0.48759 ± 584 (152)764 ± 650 (276)702 ± 581 (128)0.72
rs4969017T/C0.03765 ± 626 (529)579 ± 297 (20)195 ± 0 (1)0.14
DIrs1037257C/T0.371,375 ± 1,279 (207)1,225 ± 1,201 (280)1,390 ± 1,345 (85)0.053
rs4969076C/G0.221,397 ± 1,414 (315)1,130 ± 893 (198)1,553 ± 1,539 (30)0.34
rs1037260T/G0.131,273 ± 1,229 (470)1,485 ± 1,409 (94)1,207 ± 1,052 (5)0.62
rs11077670G/A0.141,344 ± 1,309 (398)1,133 ± 1,027 (139)1,655 ± 1,780 (8)0.036
rs1868486G/T0.301,360 ± 1,349 (254)1,342 ± 1,283 (232)1,027 ± 939 (73)0.0020
rs714925A/G0.301,348 ± 1,337 (244)1,327 ± 1,202 (243)979 ± 838 (71)0.0010
rs998571A/G0.291,352 ± 1,292 (261)1,388 ± 1,366 (219)994 ± 837 (73)0.0010
rs7220818A/G0.371,254 ± 1,176 (216)1,262 ± 1,280 (268)1,597 ± 1,404 (91)0.052
rs6501603T/G0.481,463 ± 1,437 (152)1,230 ± 1,176 (276)1,227 ± 1,004 (128)0.68
rs4969017T/C0.031,328 ± 1,293 (529)1,100 ± 975 (20)197 ± 0 (1)0.94
FBGrs1037257C/T0.3793.28 ± 9.35 (220)93.85 ± 10.25 (298)92.88 ± 9.68 (88)0.62
rs4969076C/G0.2293.57 ± 10.24 (343)93.69 ± 9.01 (202)91.16 ± 8.15 (32)0.043
rs1037260T/G0.1393.26 ± 9.55 (498)94.35 ± 10.48 (99)94.07 ± 11.80 (7)0.14
rs11077670G/A0.1493.57 ± 9.99 (427)93.38 ± 9.49 (144)96.31 ± 11.29 (8)0.41
rs1868486G/T0.3092.49 ± 9.70 (272)94.62 ± 10.02 (243)94.24 ± 9.35 (77)0.019
rs714925A/G0.3092.34 ± 9.52 (264)94.48 ± 10.00 (253)94.05 ± 9.58 (75)0.005
rs998571A/G0.2992.41 ± 9.48 (280)94.24 ± 10.27 (230)94.23 ± 9.32 (77)0.014
rs7220818A/G0.3793.86 ± 9.46 (222)93.88 ± 10.00 (286)90.96 ± 9.23 (101)0.014
rs6501603T/G0.4893.30 ± 9.76 (166)94.12 ± 10.37 (293)92.52 ± 8.86 (132)0.25
rs4969017T/C0.0393.50 ± 9.69 (562)90.59 ± 9.68 (22)93.00 ± 0.00 (1)0.19
  • Boldface data indicate P values <0.05.

  • *Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).

  • †Major/minor alleles.

  • ‡Test for association among each SNP-trait combination using a series of generalized estimating equations.