TABLE 3

Genotypic means for quantitative measures of glucose homeostasis calculated in set 2 of the IRASFS Hispanic-American population

PhenotypeSNPAllelesMAFGenotypic means ± SD (n)*
P
1/11/22/2
SIrs1037257C/T0.402.35 ± 1.78 (143)2.08 ± 1.78 (218)2.34 ± 1.91 (61)0.60
rs4969076C/G0.222.31 ± 1.85 (34)2.15 ± 1.75 (162)1.82 ± 1.53 (25)0.15
rs1037260T/G0.152.19 ± 1.72 (330)2.28 ± 1.99 (92)3.19 ± 1.55 (2)0.83
rs11077670G/A0.102.29 ± 1.84 (318)1.96 ± 1.69 (88)1.81 ± 1.57 (6)0.039
rs1868486G/T0.282.24 ± 1.78 (199)2.23 ± 1.79 (191)1.68 ± 1.72 (36)0.038
rs714925A/G0.282.27 ± 1.81 (196)2.25 ± 1.79 (191)1.69 ± 1.75 (35)0.097
rs998571A/G0.252.26 ± 1.79 (214)2.21 ± 1.79 (178)1.70 ± 1.64 (36)0.11
rs7220818A/G0.412.17 ± 1.72 (132)2.20 ± 1.76 (219)2.18 ± 1.85 (72)0.98
rs6501603T/G0.452.35 ± 1.79 (141)2.11 ± 1.77 (203)2.22 ± 1.92 (73)0.61
rs4969017T/C0.022.21 ± 1.79 (417)2.00 ± 1.66 (16)0.15
AIRrs1037257C/T0.40697 ± 629 (143)820 ± 739 (218)841 ± 695 (61)0.32
rs4969076C/G0.22773 ± 664 (234)748 ± 692 (162)776 ± 829 (25)0.80
rs1037260T/G0.15740 ± 681 (330)867 ± 712 (92)455 ± 6 (2)0.34
rs11077670G/A0.10773 ± 641 (318)815 ± 886 (88)831 ± 358 (6)0.84
rs1868486G/T0.28773 ± 676 (199)797 ± 727 (191)618 ± 593 (36)0.021
rs714925A/G0.28777 ± 671 (196)794 ± 727 (191)629 ± 605 (35)0.089
rs998571A/G0.25786 ± 660 (214)777 ± 740 (178)643 ± 596 (36)0.26
rs7220818A/G0.41757 ± 626 (132)789 ± 744 (219)747 ± 646 (72)0.86
rs6501603T/G0.45709 ± 602 (141)781 ± 708 (203)933 ± 837 (73)0.66
rs4969017T/C0.02744 ± 661 (417)1,236 ± 1,130 (16)0.12
DIrs1037257C/T0.401,270 ± 1,017 (151)1,375 ± 1,245 (218)1,520 ± 1,499 (61)0.56
rs4969076C/G0.221,426 ± 1,247 (234)1,255 ± 1,152 (162)1,122 ± 1,149 (25)0.0050
rs1037260T/G0.151,307 ± 1,163 (330)1,462 ± 1,321 (92)1,445 ± 685 (2)0.53
rs11077670G/A0.101,415 ± 1,236 (318)1,143 ± 1,106 (88)1,468 ± 1,524 (6)0.0010
rs1868486G/T0.281,305 ± 1,049 (199)1,436 ± 1,311 (191)1,035 ± 1,402 (36)0.088
rs714925A/G0.281,315 ± 1,032 (196)1,430 ± 1,309 (191)1,072 ± 1,457 (35)0.21
rs998571A/G0.251,380 ± 1,158 (214)1,353 ± 1,216 (178)1,096 ± 1,430 (36)0.20
rs7220818A/G0.411,443 ± 1,339 (132)1,294 ± 1,106 (219)1,265 ± 1,098 (72)0.63
rs6501603T/G0.451,312 ± 1,180 (141)1,313 ± 1,161 (203)1,578 ± 1,409 (73)0.32
rs4969017T/C0.021,323 ± 1,200 (417)1,540 ± 1,199 (16)0.59
FBGrs1037257C/T0.4092.68 ± 9.98 (151)93.40 ± 9.01 (231)93.93 ± 7.27 (63)0.21
rs4969076C/G0.2293.31 ± 9.04 (246)92.47 ± 9.20 (172)97.52 ± 10.32 (26)0.18
rs1037260T/G0.1593.43 ± 9.46 (350)92.38 ± 7.98 (95)90.33 ± 7.94 (3)0.53
rs11077670G/A0.1092.75 ± 8.99 (336)94.68 ± 9.83 (92)97.75 ± 5.40 (6)0.099
rs1868486G/T0.2893.43 ± 9.53 (212)92.18 ± 8.51 (199)97.41 ± 9.63 (39)0.024
rs714925A/G0.2893.40 ± 9.59 (209)92.24 ± 8.46 (199)97.87 ± 9.44 (38)0.030
rs998571A/G0.2593.34 ± 9.47 (229)92.59 ± 8.55 (185)96.25 ± 10.56 (38)0.51
rs7220818A/G0.4193.89 ± 8.88 (143)92.88 ± 9.09 (226)93.29 ± 10.29 (77)0.64
rs6501603T/G0.4593.02 ± 9.20 (147)93.15 ± 9.01 (217)93.91 ± 9.27 (76)0.60
rs4969017T/C0.0293.28 ± 9.24 (438)92.92 ± 8.70 (18)0.92
  • Boldface data indicate P values <0.05.

  • *Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).

  • †Major/minor alleles.

  • ‡Test for association among each SNP-trait combination using a series of generalized estimating equations.