TABLE 4

Genotypic means for quantitative measures of glucose homeostasis calculated in the combined IRASFS Hispanic-American population

PhenotypeSNPAllelesMAFGenotypic means ± SD (n)*
PP§
1/11/22/2
SIrs1037257C/T0.382.36 ± 2.04 (350)2.01 ± 1.68 (498)2.22 ± 2.057 (146)0.600.16
rs4969076C/G0.222.21 ± 1.95 (549)2.09 ± 1.72 (360)2.05 ± 1.93 (55)0.430.41
rs1037260T/G0.142.13 ± 1.83 (800)2.26 ± 2.02 (186)2.47 ± 1.63 (7)0.830.75
rs11077670G/A0.122.18 ± 1.92 (716)2.11 ± 1.80 (227)1.92 ± 1.84 (14)0.240.62
rs1868486G/T0.292.23 ± 1.94 (453)2.16 ± 1.86 (423)1.76 ± 1.61 (109)0.0000710.0025
rs714925A/G0.292.23 ± 1.94 (440)2.15 ± 1.85 (434)1.74 ± 1.55 (106)0.00100.0030
rs998571A/G0.272.25 ± 1.91 (475)2.17 ± 1.89 (397)1.71 ± 1.50 (109)0.000180.0024
rs7220818A/G0.392.02 ± 1.69 (348)2.15 ± 1.86 (487)2.48 ± 2.14 (163)0.600.16
rs6501603T/G0.472.31 ± 1.99 (293)2.07 ± 1.82 (479)2.17 ± 1.79 (201)0.290.13
rs4969017T/C0.032.17 ± 1.89 (946)1.98 ± 1.37 (36)1.01 ± 0.00 (1)0.830.94
AIRrs1037257C/T0.38706 ± 579 (350)777 ± 675 (498)844 ± 708 (146)0.320.16
rs4969076C/G0.22781 ± 640 (549)721 ± 635 (360)800 ± 719 (55)0.480.66
rs1037260T/G0.14754 ± 659 (800)814 ± 643 (186)496 ± 147 (7)0.500.78
rs11077670G/A0.12772 ± 629 (716)730 ± 725 (227)882 ± 586 (14)0.370.55
rs1868486G/T0.29747 ± 599 (453)799 ± 715 (423)710 ± 664 (109)0.430.58
rs714925A/G0.29750 ± 598 (440)798 ± 711 (434)711 ± 675 (106)0.480.56
rs998571A/G0.27751 ± 590 (475)796 ± 730 (397)731 ± 667 (109)0.990.99
rs7220818A/G0.39776 ± 636 (348)762 ± 687 (487)741 ± 601 (163)0.900.96
rs6501603T/G0.47735 ± 592 (293)771 ± 674 (479)786 ± 692 (201)0.460.47
rs4969017T/C0.03756 ± 641 (946)871 ± 839 (36)195 ± 0 (1)0.750.25
DIrs1037257C/T0.381,332 ± 1,179 (350)1,290 ± 1,221 (498)1,444 ± 1,408 (146)0.560.92
rs4969076C/G0.221,409 ± 1,344 (549)1,186 ± 1,018 (360)1,357 ± 1,380 (55)0.0510.036
rs1037260T/G0.141,287 ± 1,201 (800)1,474 ± 1,362 (186)1,275 ± 910 (7)0.820.90
rs11077670G/A0.121,376 ± 1,277 (716)1,137 ± 1,056 (227)1,575 ± 1,615 (14)0.000250.015
rs1868486G/T0.291,335 ± 1,225 (453)1,385 ± 1,295 (423)1,030 ± 1,107 (109)0.000370.0075
rs714925A/G0.291,333 ± 1,209 (440)1,373 ± 1,250 (434)1,009 ± 1,076 (106)0.00100.0061
rs998571A/G0.271,365 ± 1,233 (475)1,373 ± 1,299 (397)1,028 ± 1,064 (109)0.00300.027
rs7220818A/G0.391,326 ± 1,242 (348)1,277 ± 1,203 (487)1,450 ± 1,285 (163)0.0700.14
rs6501603T/G0.471,391 ± 1,320 (293)1,265 ± 1,169 (479)1,355 ± 1,177 (201)0.300.24
rs4969017T/C0.031,326 ± 1,252 (946)1,295 ± 1,087 (36)197 ± 0 (1)0.660.47
FBGrs1037257C/T0.3893.03 ± 9.60 (371)93.65 ± 9.72 (529)93.31 ± 8.74 (151)0.210.87
rs4969076C/G0.2293.46 ± 9.75 (589)93.13 ± 9.10 (374)94.01 ± 9.65 (58)0.470.54
rs1037260T/G0.1493.33 ± 9.51 (848)93.38 ± 9.37 (194)92.95 ± 10.49 (10)0.910.74
rs11077670G/A0.1293.21 ± 9.56 (763)93.89 ± 9.63 (236)96.93 ± 8.97 (14)0.0560.11
rs1868486G/T0.2992.90 ± 9.63 (484)93.52 ± 9.44 (442)95.31 ± 9.52 (116)0.0100.083
rs714925A/G0.2992.81 ± 9.56 (473)93.49 ± 9.41 (452)95.34 ± 9.66 (113)0.0100.045
rs998571A/G0.2792.83 ± 9.48 (509)93.51 ± 9.57 (415)94.90 ± 9.75 (115)0.0100.079
rs7220818A/G0.3993.87 ± 11.96 (365)93.44 ± 1097 (513)91.96 ± 9.74 (178)0.100.25
rs6501603T/G0.4793.17 ± 9.49 (313)93.71 ± 9.82 (510)93.03 ± 9.02 (208)0.760.72
rs4969017T/C0.0393.40 ± 9.49 (1000)91.64 ± 9.21 (40)93.00 ± 0.00 (1)0.410.81
  • Boldface data indicate P values <0.05.

  • *Genotypic means ± SD (n) for homozygotes of the major allele (1/1) as well as heterozygotes (1/2) and homozygotes of the minor allele (2/2).

  • †Major/minor alleles.

  • ‡Test for association among each SNP-trait combination using a series of generalized estimating equations.

  • §Meta-analysis P value computed by sequential oligogenic linkage analysis with the modeling of set 1 or set 2 affiliation as a random effect in a variance component–measured genotype model.