TABLE 2

Top WNT-SNPs reaching P< 0.01 in three study meta-analyses

SNPChromosomePositionRisk/non-risk alleleRisk frequencyThree study ORThree study P
TCF7L2rs450656510114746031T/A0.391.34 (1.26–1.42)4.48E-19
SMAD3rs71783471565108440T/C0.351.11 (1.05–1.18)0.0006
PRICKLE1rs17963901241164871T/C0.281.11 (1.04–1.19)0.001
FZD10rs374157112129161657T/C0.061.22 (1.08–1.38)0.002
DKK1rs11947421053883556G/A0.051.25 (1.09–1.44)0.002
SOX17rs2656272855424453A/G0.41.1 (1.04–1.17)0.002
FBXW11rs338305171080775A/T0.361.1 (1.03–1.17)0.003
CSNK2A2rs25503801656813871C/T0.261.11 (1.04–1.19)0.003
CCND2rs11833537124150368C/T0.411.09 (1.03–1.16)0.003
BTRCrs443648510103235351G/C0.631.09 (1.03–1.16)0.004
PPARDrs9470015635477062A/G0.191.12 (1.04–1.22)0.004
SFRP2rs117325814155077843C/T0.961.28 (1.08–1.51)0.004
WNT2Brs22733681112775813C/T0.821.1 (1.03–1.18)0.005
DKK2rs100288344108211197T/G0.081.16 (1.04–1.3)0.007
CSNK1A1Lrs95762221336687910C/T0.241.09 (1.03–1.16)0.007
NFAT5rs169590251668253090T/G0.841.11 (1.03–1.2)0.008
CAMK2Drs68509804115067898G/A0.341.08 (1.02–1.15)0.009
  • Allele frequency is based on WTCCC case samples. Three study P values are from the imputed meta-analysis of WTCCC, DGI, and FUSION cohorts, produced by the DIAGRAM consortium. SNP and gene positions are based on NCBI Build 35. Alleles are based on the forward strand.