TABLE 1

Partial pancreatectomy and high-dose exendin-4 treatment

Age (months)Body weight (g) in The Jackson Laboratory cohort
Sham operated (control)
Partial pancreatectomy
InitialFinalChangeInitialFinalChangeP
230.9 ± 1.125.6 ± 1.45.3 ± 0.530.2 ± 0.926.0 ± 0.84.2 ± 0.20.387
838.1 ± 1.133.0 ± 0.45.1 ± 0.736.9 ± 1.431.9 ± 1.55.0 ± 0.40.307
1242.2 ± 2.535.7 ± 1.76.5 ± 1.541.7 ± 2.533.3 ± 0.98.0 ± 2.40.914
1445.3 ± 2.637.1 ± 1.78.2 ± 1.136.4 ± 6.628.2 ± 4.78.1 ± 2.40.749
1948.9 ± 2.444.7 ± 2.24.1 ± 0.946.9 ± 4.040.6 ± 3.54.4 ± 0.70.923
Age (months)Body glucose (mg/dl) in The Jackson Laboratory cohort
Sham operated (control)
Partial pancreatectomy
InitialFinalAverageInitialFinalPAverageP
2135 ± 10122 ± 9121 ± 9135 ± 11145 ± 100.117143 ± 50.063
8121 ± 7120 ± 11114 ± 7137 ± 7122 ± 90.857123 ± 40.307
12136 ± 7134 ± 13131 ± 4132 ± 9137 ± 90.838131 ± 70.914
14139 ± 9131 ± 6124 ± 6131 ± 6108 ± 80.794121 ± 40.749
19115 ± 8132 ± 6125 ± 6109 ± 7139 ± 90.783125 ± 30.923
Age (months)Body weight (g) in the Taconic Farms cohort
Sham operated (control)
Partial pancreatectomy
InitialFinalChangeInitialFinalChangeP
231.7 ± 1.130.6 ± 0.91.1 ± 0.929.7 ± 0.428.4 ± 1.11.3 ± 1.40.928
1942.4 ± 5.139.1 ± 5.73.3 ± 1.142.0 ± 2.736.8 ± 1.45.2 ± 1.70.401
Age (months)Body glucose (mg/dl) in the Taconic Farms cohort
Sham operated (control)
Partial pancreatectomy
InitialFinalAverageInitialFinalPAverageP
2134 ± 12126 ± 12128 ± 8127 ± 7132 ± 110.117131 ± 70.570
1994 ± 9100 ± 1198 ± 886 ± 9103 ± 110.78392 ± 50.605
  • Data are means ± SEM for four to seven mice per group except the 19-month-old partial pancreatectomy cohort, which consisted of only three mice. Body weight of mice before and 2 weeks after a sham operation (top left) or partial pancreatectomy (top right). Random-fed blood glucose values for 2 weeks following sham operation or partial pancreatectomy, expressed as average values (middle left) or area under the curve (middle right).