TABLE 2

β-Cell morphometry

Age (months)
28121419
Pancreatic weight (mg)
    Sham operated (control)253 ± 13301 ± 19ND331 ± 6386 ± 24
    Partial pancreatectomy
Resected (splenic)127 ± 5169 ± 15ND184 ± 3187 ± 9
Remaining (duodenal)108 ± 32113 ± 18ND204 ± 6212 ± 27
β-Cell area (%)
    Sham operated (control)0.61 ± 0.090.85 ± 0.17ND1.27 ± 0.282.04 ± 0.36
    Partial pancreatectomy
Resected (splenic)0.72 ± 0.111.05 ± 0.13ND1.90 ± 0.612.60 ± 0.61
Remaining (duodenal)0.60 ± 0.040.79 ± 0.12ND1.28 ± 0.202.07 ± 0.55
β-Cell mass (mg)
    Sham operated (control)
Whole pancreas1.57 ± 0.262.46 ± 0.41ND4.15 ± 0.897.89 ± 1.59
    Partial pancreatectomy
Resected (splenic)0.98 ± 0.141.81 ± 0.31ND3.48 ± 1.124.76 ± 1.07
Remaining (duodenal)0.78 ± 0.230.93 ± 0.23ND2.59 ± 0.364.72 ± 1.75
Acinar proliferation (% BrdU/total)
    Sham operated (control)0.72 ± 0.080.57 ± 0.07ND0.41 ± 0.070.53 ± 0.11
    Partial pancreatectomy1.47 ± 0.281.64 ± 0.14ND1.62 ± 0.241.07 ± 0.1
    P0.040.0002ND0.0010.02
  • Data are means ± SEM for four to seven mice per group except the 19-month-old partial pancreatectomy cohort, which consisted of only three mice. Data show pancreatic weight of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as milligrams; β-cell area of sham-operated, resected (splenic portion), or remaining pancreas (duodenal portion) following partial pancreatectomy, expressed as percent total pancreas; β-cell mass of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as percent total pancreas; and acinar proliferation of sham-operated, resected, or remaining pancreas following partial pancreatectomy, expressed as percent total pancreas. ND, not determined.