TABLE 1

Baseline clinical characteristics of the GoKinD collection

JDC GoKinD control subjectsJDC GoKinD case subjectsGWU GoKinD control subjectsGWU GoKinD case subjects
n472441413379
Men/women220/252233/208143/270190/189
Age at diagnosis of type 1 diabetes (years)12.9 ± 7.511.5 ± 6.712.9 ± 7.212.1 ± 6.6
Duration of type 1 diabetes (years)*26.4 ± 8.027.0 ± 7.824.2 ± 7.325.9 ± 7.6
Age at examination (years)39.4 ± 6.542.0 ± 7.137.1 ± 8.844.4 ± 6.5
Laser treatment (%)22841085
A1C(%)7.5 ± 1.78.5 ± 1.67.4 ± 1.17.8 ± 1.4
ACR in control subjects (μg/mg)7.0 ± 3.76.3 ± 3.6
Case subjects with proteinuria/ESRD235/20649/330
ACR in subjects with proteinuria (μg/mg)1,571 ± 1,5341,282 ± 1,096
ESRD duration (years)7.5 ± 5.47.2 ± 5.6
Kidney transplant (%)8695
  • Clinical characteristics are the mean values ± SD for all Caucasian patients (n = 1,705) included in the current analysis after the application of quality control metrics (see supplemental information regarding sample quality control analysis and population substructure and ancestry analysis).

  • *The duration of type 1 diabetes in control subjects and in subjects with proteinuria is based on the duration at examination. Among ESRD case subjects, this is based on the duration of type 1 diabetes at the onset of ESRD. All other clinical characteristics are based on measurements performed at examination.

  • †Mean A1C values do not include data from case subjects that have undergone pancreas transplantation (11% of JDC case subjects and 58% of GWU case subjects);

  • ‡percentages are of ESRD group.