Baseline clinical characteristics of the GoKinD collection
| JDC GoKinD control subjects | JDC GoKinD case subjects | GWU GoKinD control subjects | GWU GoKinD case subjects | |
|---|---|---|---|---|
| n | 472 | 441 | 413 | 379 |
| Men/women | 220/252 | 233/208 | 143/270 | 190/189 |
| Age at diagnosis of type 1 diabetes (years) | 12.9 ± 7.5 | 11.5 ± 6.7 | 12.9 ± 7.2 | 12.1 ± 6.6 |
| Duration of type 1 diabetes (years)* | 26.4 ± 8.0 | 27.0 ± 7.8 | 24.2 ± 7.3 | 25.9 ± 7.6 |
| Age at examination (years) | 39.4 ± 6.5 | 42.0 ± 7.1 | 37.1 ± 8.8 | 44.4 ± 6.5 |
| Laser treatment (%) | 22 | 84 | 10 | 85 |
| A1C(%)† | 7.5 ± 1.7 | 8.5 ± 1.6 | 7.4 ± 1.1 | 7.8 ± 1.4 |
| ACR in control subjects (μg/mg) | 7.0 ± 3.7 | — | 6.3 ± 3.6 | — |
| Case subjects with proteinuria/ESRD | 235/206 | 49/330 | ||
| ACR in subjects with proteinuria (μg/mg) | 1,571 ± 1,534 | 1,282 ± 1,096 | ||
| ESRD duration (years) | 7.5 ± 5.4 | 7.2 ± 5.6 | ||
| Kidney transplant (%)‡ | 86 | 95 |
Clinical characteristics are the mean values ± SD for all Caucasian patients (n = 1,705) included in the current analysis after the application of quality control metrics (see supplemental information regarding sample quality control analysis and population substructure and ancestry analysis).
*The duration of type 1 diabetes in control subjects and in subjects with proteinuria is based on the duration at examination. Among ESRD case subjects, this is based on the duration of type 1 diabetes at the onset of ESRD. All other clinical characteristics are based on measurements performed at examination.
†Mean A1C values do not include data from case subjects that have undergone pancreas transplantation (11% of JDC case subjects and 58% of GWU case subjects);
‡percentages are of ESRD group.