TABLE 2

Linear regression model of maximum A1C reduction

420del
R61C
CoefficientPCoefficientP
Genotype0.0340.4700.0070.919
Baseline A1C0.743<0.00010.743<0.0001
Creatinine clearance−0.1750.025−0.1750.025
Average dose−0.0040.595−0.0040.582
Adherence0.081<0.00010.081<0.0001
Group−0.314<0.0001−0.315<0.0001
  • The coefficients are for the average dose per 100 mg, for creatinine clearance per 100 ml/min, and for adherence per 10% change. The genotypes were coded as the dosage of mutant alleles.